期刊
DNA REPAIR
卷 38, 期 -, 页码 50-57出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2015.11.013
关键词
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资金
- German Science Foundation (Deutsche Forschungsgemeinschaft) GRK 1384
- Chinese Scholary Council
The principal DNA mismatch repair proteins MutS and MutL are versatile enzymes that couple DNA mismatch or damage recognition to other cellular processes. Besides interaction with their DNA substrates this involves transient interactions with other proteins which is triggered by the DNA mismatch or damage and controlled by conformational changes. Both MutS and MutL proteins have ATPase activity, which adds another level to control their activity and interactions with DNA substrates and other proteins. Here we focus on the protein-protein interactions, protein interaction sites and the different levels of structural knowledge about the protein complexes formed with MutS and MutL during the mismatch repair reaction. (C) 2015 Elsevier B.V. All rights reserved.
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