期刊
NEURAL COMPUTATION
卷 33, 期 1, 页码 41-66出版社
MIT PRESS
DOI: 10.1162/neco_a_01342
关键词
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资金
- CNRS
- European Community (Human Brain Project) [H2020-785907]
- ICODE excellence network
The study highlights the limitations of the adaptive exponential integrate-and-fire model and proposes the conductance-based adaptive exponential integrate-and-fire model as a solution to avoid unrealistic behaviors, demonstrating its dynamic characteristics and the variety of firing patterns it can produce.
The intrinsic electrophysiological properties of single neurons can be described by a broad spectrum of models, from the most realistic Hodgkin-Huxley-type models with numerous detailed mechanisms to the phenomenological models. The adaptive exponential integrate-and-fire (AdEx) model has emerged as a convenient middle-ground model. With a low computational cost but keeping biophysical interpretation of the parameters, it has been extensively used for simulations of large neural networks. However, because of its current-based adaptation, it can generate unrealistic behaviors. We show the limitations of the AdEx model, and to avoid them, we introduce the conductance-based adaptive exponential integrate-and-fire model (CAdEx). We give an analysis of the dynamics of the CAdEx model and show the variety of firing patterns it can produce. We propose the CAdEx model as a richer alternative to perform network simulations with simplified models reproducing neuronal intrinsic properties.
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