Experimental and computational technologies to dissect the kidney at the single-cell level

The field of single-cell technologies, in particular single-cell genomics with transcriptomics and epigenomics, and most recently single-cell proteomics, is rapidly growing and holds promise to advance our understanding of organ homoeostasis and disease, and facilitate the identification of novel therapeutic targets and biomarkers. This review offers an introduction to these technologies. In addition, as the size and complexity of the data require sophisticated computational methods for analysis and interpretation, we will also provide an overview of these methods and summarize the single-cell literature specifically pertaining to the kidney.

Automated summary

The field of single-cell technologies, including genomics, transcriptomics, and proteomics, is rapidly advancing and has the potential to enhance our understanding of organ homeostasis and disease, as well as identify new therapeutic targets and biomarkers. This review provides an introduction to these technologies and summarizes the single-cell literature specifically related to the kidney.