How to diSARM the executioner of axon degeneration

The protein SARM1 is an executioner of axon degeneration through its NAD(+) hydrolase activity. Three groups now report structures of human SARM1 in an inactive state and identify NAD(+) as an allosteric inhibitor, illuminating an elegant mechanism of how SARM1 is activated at lower NAD(+) levels and causes NAD(+) collapse and axon degeneration.

Automated summary

SARM1 protein acts as an executioner of axon degeneration through its NAD(+) hydrolase activity. Studies have shown that it is activated at lower NAD(+) levels and causes NAD(+) collapse and axon degeneration.