期刊
DNA REPAIR
卷 44, 期 -, 页码 143-150出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2016.05.020
关键词
PIKK; ATR; Cellular plasticity; Nuclear envelope; Nucleolus; Centrosome
资金
- Marie Curie Initial Training Networks (ITN) (FP7 'aDDRess') fellowship
- AIRC
- European Commission
- CSIR
- Department of Science and Technology, India
- Telethon-Italy
ATR (Ataxia Telangiectasia and Rad3-related) is a member of the Phosphatidylinositol 3-kinase-related kinases (PIKKs) family, amongst six other vertebrate proteins known so far. ATR is indispensable for cell survival and its essential role is in sensing DNA damage and initiating appropriate repair responses. In this review we highlight emerging and recent observations connecting ATR to alternative roles in controlling the nuclear envelope, nucleolus, centrosome and other organelles in response to both internal and external stress conditions. We propose that ATR functions control cell plasticity by sensing structural deformations of different cellular components, including DNA and initiating appropriate repair responses, most of which are yet to be understood completely. (C) 2016 The Authors. Published by Elsevier B.V.
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