期刊
DNA REPAIR
卷 44, 期 -, 页码 136-142出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.dnarep.2016.05.019
关键词
Cyclin; Dependent kinases; ERCC2/xeroderma pigmentosum D (XPD); Helicases; Iron-sulfur cluster; Mitosis; Spindle pole; TFIIH
资金
- National Institutes of Health [5R01ES019566, 1R21ES025606, 2P30CA047904]
- Deutsche Forschungsgemeinschaft [KI 562/7-1]
XPD, as part of the TFIIH complex, has classically been linked to the damage verification step of nucleotide excision repair (NER). However, recent data indicate that XPD, due to its iron-sulfur center interacts with the iron sulfur cluster assembly proteins, and may interact with other proteins in the cell to mediate a diverse set of biological functions including cell cycle regulation, mitosis, and mitochondria( function. In this perspective, after first reviewing the function and some of the key disease causing variants that affect XPD's interaction with TFIIH and the CDK-activating kinase complex (CAK), we investigate these intriguing cellular roles of XPD and highlight important unanswered questions that provide a fertile ground for further scientific exploration. (C) 2016 Published by Elsevier B.V.
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