相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Establishing or Exaggerating Causality for the Gut Microbiome: Lessons from Human Microbiota-Associated Rodents
Jens Walter et al.
CELL (2020)
Long-Term Changes in Gut Microbial Metabolite Trimethylamine N-Oxide and Coronary Heart Disease Risk
Yoriko Heianza et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)
Heterochromatin protein 1α interacts with parallel RNA and DNA G-quadruplexes
Ruby J. Roach et al.
NUCLEIC ACIDS RESEARCH (2020)
Selecting likely causal risk factors from high-throughput experiments using multivariable Mendelian randomization
Verena Zuber et al.
NATURE COMMUNICATIONS (2020)
Transcriptional and Cellular Diversity of the Human Heart
Nathan R. Tucker et al.
CIRCULATION (2020)
Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis
Tom G. Richardson et al.
PLOS MEDICINE (2020)
Gut Microbiota-Dependent Trimethylamine N-oxide and Cardiovascular Outcomes in Patients With Prior Myocardial Infarction: A Nested Case Control Study From the PEGASUS-TIMI 54 Trial
Baris Gencer et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION (2020)
Statin therapy is associated with lower prevalence of gut microbiota dysbiosis
Sara Vieira-Silva et al.
NATURE (2020)
Evaluating drug targets through human loss-of-function genetic variation
Eric Vallabh Minikel et al.
NATURE (2020)
Prediction of mortality from 12-lead electrocardiogram voltage data using a deep neural network
Sushravya Raghunath et al.
NATURE MEDICINE (2020)
Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers
Nina Mars et al.
NATURE MEDICINE (2020)
Genomic Analysis in the Age of Human Genome Sequencing
Tuuli Lappalainen et al.
CELL (2019)
Association of Triglyceride-Lowering LPL Variants and LDL-C-Lowering LDLR Variants With Risk of Coronary Heart Disease
Brian A. Ference et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2019)
Artificial Intelligence in Cardiovascular Imaging JACC State-of-the-Art Review
Damini Dey et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)
Mendelian Randomization Study of ACLY and Cardiovascular Disease
Brian A. Ference et al.
NEW ENGLAND JOURNAL OF MEDICINE (2019)
Safety and Efficacy of Bempedoic Acid to Reduce LDL Cholesterol
Kausik K. Ray et al.
NEW ENGLAND JOURNAL OF MEDICINE (2019)
Trans Effects on Gene Expression Can Drive Omnigenic Inheritance
Xuanyao Liu et al.
CELL (2019)
An atlas of polygenic risk score associations to highlight putative causal relationships across the human phenome
Tom G. Richardson et al.
ELIFE (2019)
Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies
Mashaal Sohail et al.
ELIFE (2019)
Reduced signal for polygenic adaptation of height in UK Biobank
Jeremy J. Berg et al.
ELIFE (2019)
The Translational Landscape of the Human Heart
Sebastiaan van Heesch et al.
CELL (2019)
A Bayesian mixture model for clustering droplet-based single-cell transcriptomic data from population studies
Zhe Sun et al.
NATURE COMMUNICATIONS (2019)
Systems Pharmacology Identifies an Arterial Wall Regulatory Gene Network Mediating Coronary Artery Disease Side Effects of Antiretroviral Therapy
Itziar Frades et al.
CIRCULATION-GENOMIC AND PRECISION MEDICINE (2019)
Assessment of network module identification across complex diseases
Sarvenaz Choobdar et al.
NATURE METHODS (2019)
High-definition spatial transcriptomics for in situ tissue profiling
Sanja Vickovic et al.
NATURE METHODS (2019)
Genetic regulatory variation in populations informs transcriptome analysis in rare disease
Pejman Mohammadi et al.
SCIENCE (2019)
Genetic architecture of human plasma lipidome and its link to cardiovascular disease
Rubina Tabassum et al.
NATURE COMMUNICATIONS (2019)
A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context
Apolline Gallois et al.
NATURE COMMUNICATIONS (2019)
An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings
Eleanor Sanderson et al.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2019)
Targeted inhibition of gut microbiota proteins involved in TMAO production to reduce platelet aggregation and arterial thrombosis: a blueprint for drugging the microbiota in the treatment of cardiometabolic disease?
T. E. van Mens et al.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2019)
Plasma protein patterns as comprehensive indicators of health
Stephen A. Williams et al.
NATURE MEDICINE (2019)
Undulating changes in human plasma proteome profiles across the lifespan
Benoit Lehallier et al.
NATURE MEDICINE (2019)
Temporal Trends in Unstable Angina Diagnosis Codes for Outpatient Percutaneous Coronary Interventions
Rishi K. Wadhera et al.
JAMA INTERNAL MEDICINE (2019)
Predictive value of targeted proteomics for coronary plaque morphology in patients with suspected coronary artery disease
Michiel J. Bom et al.
EBIOMEDICINE (2019)
High-Throughput Plasma Lipidomics: Detailed Mapping of the Associations with Cardiometabolic Risk Factors
Kevin Huynh et al.
CELL CHEMICAL BIOLOGY (2019)
Gut Microbiota-Dependent Trimethylamine N-Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes
Arash Haghikia et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2018)
Common Disease Is More Complex Than Implied by the Core Gene Omnigenic Model
Naomi R. Wray et al.
CELL (2018)
Taking Systems Medicine to Heart
Kalliopi Trachana et al.
CIRCULATION RESEARCH (2018)
Emerging Role of Precision Medicine in Cardiovascular Disease
Jane A. Leopold et al.
CIRCULATION RESEARCH (2018)
Current understanding of the human microbiome
Jack A. Gilbert et al.
NATURE MEDICINE (2018)
Integrated omics dissection of proteome dynamics during cardiac remodeling
Edward Lau et al.
NATURE COMMUNICATIONS (2018)
Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets
Harri Lempiainen et al.
SCIENTIFIC REPORTS (2018)
Deciphering the Dynamic Transcriptional and Post-transcriptional Networks of Macrophages in the Healthy Heart and after Myocardial Injury
Wencke Walter et al.
CELL REPORTS (2018)
Genomic atlas of the human plasma proteome
Benjamin B. Sun et al.
NATURE (2018)
Development of a gut microbe-targeted nonlethal therapeutic to inhibit thrombosis potential
Adam B. Roberts et al.
NATURE MEDICINE (2018)
A Multi-omic Association Study of Trimethylamine N-Oxide
Ohad Manor et al.
CELL REPORTS (2018)
Unveiling the Role of the Most Impactful Cardiovascular Risk Locus through Haplotype Editing
Valentina Lo Sardo et al.
CELL (2018)
Probing the Virtual Proteome to Identify Novel Disease Biomarkers
Jonathan D. Mosley et al.
CIRCULATION (2018)
Metabolomic Consequences of Genetic Inhibition of PCSK9 Compared With Statin Treatment
Eeva Sliz et al.
CIRCULATION (2018)
Future of Personalized Cardiovascular Medicine JACC State-of-the-Art Review
Robert M. Califf
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)
Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults Implications for Primary Prevention
Michael Inouye et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2018)
Genetics of blood lipids among ∼300,000 multi-ethnic participants of the Million Veteran Program
Derek Klarin et al.
NATURE GENETICS (2018)
Cross-linking mass spectrometry: methods and applications in structural, molecular and systems biology
Francis J. O'Reilly et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
Large-scale plasma lipidomic profiling identifies lipids that predict cardiovascular events in secondary prevention
Piyushkumar A. Mundra et al.
JCI INSIGHT (2018)
Personalising the decision for prolonged dual antiplatelet therapy: development, validation and potential impact of prognosticmodels for cardiovascular events and bleeding in myocardial infarction survivors
Laura Pasea et al.
EUROPEAN HEART JOURNAL (2017)
Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques
Sarah R. Langley et al.
JOURNAL OF CLINICAL INVESTIGATION (2017)
Very-Low-Density Lipoprotein- Associated Apolipoproteins Predict Cardiovascular Events and Are Lowered by Inhibition of APOC-III
Raimund Pechlaner et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2017)
Single-cell transcriptomics reconstructs fate conversion from fibroblast to cardiomyocyte
Ziqing Liu et al.
NATURE (2017)
Genetic effects on gene expression across human tissues
Francois Aguet et al.
NATURE (2017)
Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease
Xiangfeng Lu et al.
NATURE GENETICS (2017)
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease
Wei Zhao et al.
NATURE GENETICS (2017)
Exome-wide association study of plasma lipids in >300,000 individuals
Dajiang J. Liu et al.
NATURE GENETICS (2017)
Quantitative proteomics: challenges and opportunities in basic and applied research
Olga T. Schubert et al.
NATURE PROTOCOLS (2017)
A subcellular map of the human proteome
Peter J. Thul et al.
SCIENCE (2017)
The gut microbiome in atherosclerotic cardiovascular disease
Zhuye Jie et al.
NATURE COMMUNICATIONS (2017)
Education and coronary heart disease: mendelian randomisation study
Taavi Tillmann et al.
BMJ-BRITISH MEDICAL JOURNAL (2017)
Education and coronary heart disease: mendelian randomisation study
Taavi Tillmann et al.
BMJ-BRITISH MEDICAL JOURNAL (2017)
Effect of PCSK9 Inhibitors on Clinical Outcomes in Patients With Hypercholesterolemia: A Meta-Analysis of 35 Randomized Controlled Trials
Aris Karatasakis et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION (2017)
Association Between Vascular Cell Adhesion Molecule 1 and Atrial Fibrillation
Karin Willeit et al.
JAMA CARDIOLOGY (2017)
Evaluating phecodes, clinical classification software, and ICD-9-CM codes for phenomewide association studies in the electronic health record
Wei-Qi Wei et al.
PLOS ONE (2017)
Network analysis reveals a causal role of mitochondrial gene activity in atherosclerotic lesion formation
Baiba Vilne et al.
ATHEROSCLEROSIS (2017)
Direct Comparison of Cardiac Myosin-Binding Protein C With Cardiac Troponins for the Early Diagnosis of Acute Myocardial Infarction
Thomas E. Kaier et al.
CIRCULATION (2017)
An Expanded View of Complex Traits: From Polygenic to Omnigenic
Evan A. Boyle et al.
CELL (2017)
Multi-omics approaches to disease
Yehudit Hasin et al.
GENOME BIOLOGY (2017)
Quantifying the Release of Biomarkers of Myocardial Necrosis from Cardiac Myocytes and Intact Myocardium
Jack Marjot et al.
CLINICAL CHEMISTRY (2017)
Emerging Affinity-Based Proteomic Technologies for Large-Scale Plasma Profiling in Cardiovascular Disease
J. Gustav Smith et al.
CIRCULATION (2017)
Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort
Elin Org et al.
GENOME BIOLOGY (2017)
Association of MicroRNAs and YRNAs With Platelet Function
Dorothee Kaudewitz et al.
CIRCULATION RESEARCH (2016)
Revisiting Cardiac Cellular Composition
Alexander R. Pinto et al.
CIRCULATION RESEARCH (2016)
Human SRMAtlas: A Resource of Targeted Assays to Quantify the Complete Human Proteome
Ulrike Kusebauch et al.
CELL (2016)
Mass Cytometry: Single Cells, Many Features
Matthew H. Spitzer et al.
CELL (2016)
Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
Weifei Zhu et al.
CELL (2016)
Aptamer-Based Proteomic Profiling Reveals Novel Candidate Biomarkers and Pathways in Cardiovascular Disease
Debby Ngo et al.
CIRCULATION (2016)
Cognitive Machine-Learning Algorithm for Cardiac Imaging A Pilot Study for Differentiating Constrictive Pericarditis From Restrictive Cardiomyopathy
Partho P. Sengupta et al.
CIRCULATION-CARDIOVASCULAR IMAGING (2016)
Genomic prediction of coronary heart disease
Gad Abraham et al.
EUROPEAN HEART JOURNAL (2016)
Development and Validation of a Protein-Based Risk Score for Cardiovascular Outcomes Among Patients With Stable Coronary Heart Disease
Peter Ganz et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)
MicroRNAs in Cardiovascular Disease
Temo Barwari et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2016)
Single-cell genome sequencing: current state of the science
Charles Gawad et al.
NATURE REVIEWS GENETICS (2016)
Metabolomics: beyond biomarkers and towards mechanisms
Caroline H. Johnson et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease
Amit V. Khera et al.
NEW ENGLAND JOURNAL OF MEDICINE (2016)
Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases
Oscar Franzen et al.
SCIENCE (2016)
Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans
Lesca M. Holdt et al.
NATURE COMMUNICATIONS (2016)
Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
Clint L. Miller et al.
NATURE COMMUNICATIONS (2016)
Beatquency domain and machine learning improve prediction of cardiovascular death after acute coronary syndrome
Yun Liu et al.
SCIENTIFIC REPORTS (2016)
The Cardiomyocyte RNA-Binding Proteome: Links to Intermediary Metabolism and Heart Disease
Yalin Liao et al.
CELL REPORTS (2016)
From genomic medicine to precision medicine: highlights of 2015
Charles Auffray et al.
GENOME MEDICINE (2016)
Cross-Tissue Regulatory Gene Networks in Coronary Artery Disease
Husain A. Talukdar et al.
CELL SYSTEMS (2016)
Genome-wide association study of new-onset atrial fibrillation after coronary artery bypass grafting surgery
Miklos D. Kertai et al.
AMERICAN HEART JOURNAL (2015)
Metabolite Profiling and Cardiovascular Event Risk A Prospective Study of 3 Population-Based Cohorts
Peter Wurtz et al.
CIRCULATION (2015)
Integrated Metabolomics and Genomics Systems Approaches to Biomarkers and Mechanisms of Cardiovascular Disease
Svati H. Shah et al.
Circulation-Cardiovascular Genetics (2015)
Phosphorylation of Cardiac Myosin-Binding Protein-C Is a Critical Mediator of Diastolic Function
Paola C. Rosas et al.
CIRCULATION-HEART FAILURE (2015)
Novel methodologies for biomarker discovery in atherosclerosis
Imo E. Hoefer et al.
EUROPEAN HEART JOURNAL (2015)
RNA-Seq identifies novel myocardial gene expression signatures of heart failure
Yichuan Liu et al.
GENOMICS (2015)
Association of Plasma Ceramides and Sphingomyelin With VLDL apoB-100 Fractional Catabolic Rate Before and After Rosuvastatin Treatment
Theodore W. K. Ng et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)
Systems analysis reveals down-regulation of a network of pro-survival miRNAs drives the apoptotic response in dilated cardiomyopathy
Ruth Isserlin et al.
MOLECULAR BIOSYSTEMS (2015)
Understanding multicellular function and disease with human tissue-specific networks
Casey S. Greene et al.
NATURE GENETICS (2015)
Machine learning applications in genetics and genomics
Maxwell W. Libbrecht et al.
NATURE REVIEWS GENETICS (2015)
Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia
Daniel Gaudet et al.
NEW ENGLAND JOURNAL OF MEDICINE (2015)
The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans
Kristin G. Ardlie et al.
SCIENCE (2015)
DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes
Janet Pinero et al.
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2015)
Detection of Composite Communities in Multiplex Biological Networks
Laura Bennett et al.
SCIENTIFIC REPORTS (2015)
The Human Blood Metabolome-Transcriptome Interface
Joerg Bartel et al.
PLOS GENETICS (2015)
Integrated Metabolomics and Genomics Systems Approaches to Biomarkers and Mechanisms of Cardiovascular Disease
Svati H. Shah et al.
Circulation-Cardiovascular Genetics (2015)
Phenomapping for Novel Classification of Heart Failure With Preserved Ejection Fraction
Sanjiv J. Shah et al.
CIRCULATION (2015)
Ion Coalescence of Neutron Encoded TMT 10-Plex Reporter Ions
Thilo Werner et al.
ANALYTICAL CHEMISTRY (2014)
Medical diagnosis of cardiovascular diseases using an interval-valued fuzzy rule-based classification system
Jose Antonio Sanz et al.
APPLIED SOFT COMPUTING (2014)
Lipidomics Profiling and Risk of Cardiovascular Disease in the Prospective Population-Based Bruneck Study
Christin Stegemann et al.
CIRCULATION (2014)
Genome-Scale Methods Converge on Key Mitochondrial Genes for the Survival of Human Cardiomyocytes in Hypoxia
Lindsay M. Edwards et al.
CIRCULATION-CARDIOVASCULAR GENETICS (2014)
Cardiovascular Transcriptomics and Epigenomics Using Next-Generation Sequencing Challenges, Progress, and Opportunities
Po-Yen Wu et al.
CIRCULATION-CARDIOVASCULAR GENETICS (2014)
A genome-wide association study identifies 6p21 as novel risk locus for dilated cardiomyopathy
Benjamin Meder et al.
EUROPEAN HEART JOURNAL (2014)
Gene expression and genetic variation in human atria
Honghuang Lin et al.
HEART RHYTHM (2014)
Genetic Variants at Chromosome 9p21 and Risk of First Versus Subsequent Coronary Heart Disease Events
Riyaz S. Patel et al.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2014)
Triglycerides and cardiovascular disease
Borge G. Nordestgaard et al.
LANCET (2014)
Mass-spectrometry-based draft of the human proteome
Mathias Wilhelm et al.
NATURE (2014)
Defining Disease Phenotypes Using National Linked Electronic Health Records: A Case Study of Atrial Fibrillation
Katherine I. Morley et al.
PLOS ONE (2014)
Precision phenotyping, panomics, and system-level bioinformatics to delineate complex biologies of atherosclerosis: Rationale and design of the Genetic Loci and the Burden of Atherosclerotic Lesions study
Szilard Voros et al.
JOURNAL OF CARDIOVASCULAR COMPUTED TOMOGRAPHY (2014)
CGBayesNets: Conditional Gaussian Bayesian Network Learning and Inference with Mixed Discrete and Continuous Data
Michael J. McGeachie et al.
PLOS COMPUTATIONAL BIOLOGY (2014)
Nucleic Acid Ligands With Protein-like Side Chains: Modified Aptamers and Their Use as Diagnostic and Therapeutic Agents
John C. Rohloff et al.
MOLECULAR THERAPY-NUCLEIC ACIDS (2014)
A Systems Biology Framework Identifies Molecular Underpinnings of Coronary Heart Disease
Tianxiao Huan et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2013)
Gene promoters show chromosome-specificity and reveal chromosome territories in humans
Paul Gagniuc et al.
BMC GENOMICS (2013)
Circulating MicroRNAs as Novel Biomarkers for Platelet Activation
Peter Willeit et al.
CIRCULATION RESEARCH (2013)
Exome Sequencing and Genome-Wide Linkage Analysis in 17 Families Illustrate the Complex Contribution of TTN Truncating Variants to Dilated Cardiomyopathy
Nadine Norton et al.
CIRCULATION-CARDIOVASCULAR GENETICS (2013)
Feature selection for medical diagnosis : Evaluation for cardiovascular diseases
Swati Shilaskar et al.
EXPERT SYSTEMS WITH APPLICATIONS (2013)
Genetic mutations and mechanisms in dilated cardiomyopathy
Elizabeth M. McNally et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Measuring and Managing Ratio Compression for Accurate iTRAQ/TMT Quantification
Mikhail M. Savitski et al.
JOURNAL OF PROTEOME RESEARCH (2013)
Transcriptome and genome sequencing uncovers functional variation in humans
Tuuli Lappalainen et al.
NATURE (2013)
Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
Jason D. Buenrostro et al.
NATURE METHODS (2013)
DGIdb: mining the druggable genome
Malachi Griffith et al.
NATURE METHODS (2013)
Dilated cardiomyopathy: the complexity of a diverse genetic architecture
Ray E. Hershberger et al.
NATURE REVIEWS CARDIOLOGY (2013)
Computational solutions for omics data
Bonnie Berger et al.
NATURE REVIEWS GENETICS (2013)
Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk
W. H. Wilson Tang et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Network Topology Reveals Key Cardiovascular Disease Genes
Anida Sarajlic et al.
PLOS ONE (2013)
TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
Daehwan Kim et al.
GENOME BIOLOGY (2013)
Mapping Novel Pathways in Cardiovascular Disease Using eQTL Data: The Past, Present, and Future of Gene Expression Analysis
Rajat M. Gupta et al.
Frontiers in Genetics (2013)
CardioNet: A human metabolic network suited for the study of cardiomyocyte metabolism
Anja Karlstaedt et al.
BMC SYSTEMS BIOLOGY (2012)
The Emerging Paradigm of Network Medicine in the Study of Human Disease
Stephen Y. Chan et al.
CIRCULATION RESEARCH (2012)
Meta-analysis identifies six new susceptibility loci for atrial fibrillation
Patrick T. Ellinor et al.
NATURE GENETICS (2012)
Mining electronic health records: towards better research applications and clinical care
Peter B. Jensen et al.
NATURE REVIEWS GENETICS (2012)
Chapter 13: Mining Electronic Health Records in the Genomics Era
Joshua C. Denny
PLOS COMPUTATIONAL BIOLOGY (2012)
Novel Loci for Metabolic Networks and Multi-Tissue Expression Studies Reveal Genes for Atherosclerosis
Michael Inouye et al.
PLOS GENETICS (2012)
Interactome Networks and Human Disease
Marc Vidal et al.
CELL (2011)
Protein Interaction-Based Genome-Wide Analysis of Incident Coronary Heart Disease
Majken K. Jensen et al.
CIRCULATION-CARDIOVASCULAR GENETICS (2011)
Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and Failure
Frederick E. Dewey et al.
CIRCULATION-CARDIOVASCULAR GENETICS (2011)
A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy
Eric Villard et al.
EUROPEAN HEART JOURNAL (2011)
Recurrent Neural Network for Non-Smooth Convex Optimization Problems With Application to the Identification of Genetic Regulatory Networks
Long Cheng et al.
IEEE TRANSACTIONS ON NEURAL NETWORKS (2011)
Epidemiology, epigenetics and the 'Gloomy Prospect': embracing randomness in population health research and practice
George Davey Smith
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2011)
Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies
Muredach P. Reilly et al.
LANCET (2011)
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Zeneng Wang et al.
NATURE (2011)
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Heribert Schunkert et al.
NATURE GENETICS (2011)
Using electronic health records to drive discovery in disease genomics
Isaac S. Kohane
NATURE REVIEWS GENETICS (2011)
Network medicine: a network-based approach to human disease
Albert-Laszlo Barabasi et al.
NATURE REVIEWS GENETICS (2011)
Gαq and Phospholipase C-β : Turn On, Turn Off, and Do It Fast
Elliott M. Ross
SCIENCE SIGNALING (2011)
ANRIL Expression Is Associated With Atherosclerosis Risk at Chromosome 9p21
Lesca M. Holdt et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2010)
Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease
Patrick Linsel-Nitschke et al.
ATHEROSCLEROSIS (2010)
Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes
Anna Zampetaki et al.
CIRCULATION RESEARCH (2010)
Design of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study A Genome-Wide Association Meta-analysis Involving More Than 22 000 Cases and 60 000 Controls
Michael Preuss et al.
CIRCULATION-CARDIOVASCULAR GENETICS (2010)
The Gene, Environment Association Studies Consortium (GENEVA): Maximizing the Knowledge Obtained from GWAS by Collaboration Across Studies of Multiple Conditions
Marilyn C. Cornelis et al.
GENETIC EPIDEMIOLOGY (2010)
Association Between Familial Atrial Fibrillation and Risk of New-Onset Atrial Fibrillation
Steven A. Lubitz et al.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2010)
Depletion of Abundant Plasma Proteins and Limitations of Plasma Proteomics
Chengjian Tu et al.
JOURNAL OF PROTEOME RESEARCH (2010)
Metabonomic, transcriptomic, and genomic variation of a population cohort
Michael Inouye et al.
MOLECULAR SYSTEMS BIOLOGY (2010)
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
Kiran Musunuru et al.
NATURE (2010)
Several common variants modulate heart rate, PR interval and QRS duration
Hilma Holm et al.
NATURE GENETICS (2010)
Genome-wide association study of PR interval
Arne Pfeufer et al.
NATURE GENETICS (2010)
Genetic variation in SCN10A influences cardiac conduction
John C. Chambers et al.
NATURE GENETICS (2010)
VIEWPOINT Missing heritability and strategies for finding the underlying causes of complex disease
Evan E. Eichler et al.
NATURE REVIEWS GENETICS (2010)
Single cell analysis: the new frontier in 'omics'
Daojing Wang et al.
TRENDS IN BIOTECHNOLOGY (2010)
From 'differential expression' to 'differential networking' - identification of dysfunctional regulatory networks in diseases
Alberto de la Fuente
TRENDS IN GENETICS (2010)
An Immune Response Network Associated with Blood Lipid Levels
Michael Inouye et al.
PLOS GENETICS (2010)
Genetic Association Study Identifies HSPB7 as a Risk Gene for Idiopathic Dilated Cardiomyopathy
Klaus Stark et al.
PLOS GENETICS (2010)
Gene-Environment Interaction in Genome-Wide Association Studies
Cassandra E. Murcray et al.
AMERICAN JOURNAL OF EPIDEMIOLOGY (2009)
High-throughput serum NMR metabonomics for cost-effective holistic studies on systemic metabolism
Pasi Soininen et al.
ANALYST (2009)
Genetic Variations in Nitric Oxide Synthase 1 Adaptor Protein Are Associated With Sudden Cardiac Death in US White Community-Based Populations
W. H. Linda Kao et al.
CIRCULATION (2009)
Identification of Cardiac Myosin-binding Protein C as a Candidate Biomarker of Myocardial Infarction by Proteomics Analysis
Sebastien Jacquet et al.
MOLECULAR & CELLULAR PROTEOMICS (2009)
Common variants at 30 loci contribute to polygenic dyslipidemia
Sekar Kathiresan et al.
NATURE GENETICS (2009)
mRNA-Seq whole-transcriptome analysis of a single cell
Fuchou Tang et al.
NATURE METHODS (2009)
Applying mass spectrometry-based proteomics to genetics, genomics and network biology
Matthias Gstaiger et al.
NATURE REVIEWS GENETICS (2009)
Long non-coding RNAs: insights into functions
Tim R. Mercer et al.
NATURE REVIEWS GENETICS (2009)
RNA-Seq: a revolutionary tool for transcriptomics
Zhong Wang et al.
NATURE REVIEWS GENETICS (2009)
Mapping complex disease traits with global gene expression
William Cookson et al.
NATURE REVIEWS GENETICS (2009)
Detection and interpretation of expression quantitative trait loci (eQTL)
Jacob J. Michaelson et al.
METHODS (2009)
Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome
Erez Lieberman-Aiden et al.
SCIENCE (2009)
Genetic variation at the 9p21 locus predicts angiographic coronary artery disease prevalence but not extent and has clinical utility
Jeffrey L. Anderson et al.
AMERICAN HEART JOURNAL (2008)
Four SNPs on chromosome 9p21 in a South Korean population implicate a genetic locus that confers high cross-race risk for development of coronary artery disease
Gong-Qing Shen et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2008)
Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease
Heribert Schunkert et al.
CIRCULATION (2008)
Genetic Determinants of Sudden Cardiac Death
Peter A. Noseworthy et al.
CIRCULATION (2008)
The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis
Shusheng Wang et al.
DEVELOPMENTAL CELL (2008)
Identification of dilated cardiomyopathy signature genes through gene expression and network data integration
Anyela Camargo et al.
GENOMICS (2008)
Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology
Debbie A. Lawlor et al.
STATISTICS IN MEDICINE (2008)
Association between four SNPs on chromosome 9p21 and myocardial infarction is replicated in an Italian population
Gong-Qing Shen et al.
JOURNAL OF HUMAN GENETICS (2008)
Human heart failure is associated with abnormal C-terminal splicing variants in the cardiac sodium channel
Lijuan L. Shang et al.
CIRCULATION RESEARCH (2007)
Mapping protein post-translational modifications with mass spectrometry
Eric S. Witze et al.
NATURE METHODS (2007)
Population genomics of human gene expression
Barbara E. Stranger et al.
NATURE GENETICS (2007)
Genomewide association analysis of coronary artery disease
Nilesh J. Samani et al.
NEW ENGLAND JOURNAL OF MEDICINE (2007)
A primer on learning in Bayesian networks for computational biology
Chris J. Needham et al.
PLOS COMPUTATIONAL BIOLOGY (2007)
A common variant on chromosome 9p21 affects the risk of myocardial infarction
Anna Helgadottir et al.
SCIENCE (2007)
Machine learning and its applications to biology
Adi L. Tarca et al.
PLOS COMPUTATIONAL BIOLOGY (2007)
Global reconstruction of the human metabolic network based on genomic and bibliomic data
Natalie C. Duarte et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
Martin G. Larson et al.
BMC MEDICAL GENETICS (2007)
Reverse engineering gene networks to identify key drivers of complex disease phenotypes
Eric E. Schadt et al.
JOURNAL OF LIPID RESEARCH (2006)
Functional and quantitative proteomics using SILAC
Matthias Mann
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
Genetics of global gene expression
Matthew V. Rockman et al.
NATURE REVIEWS GENETICS (2006)
A practical recipe for stable isotope labeling by amino acids in cell culture (SILAC)
Shao-En Ong et al.
NATURE PROTOCOLS (2006)
C-reactive protein and its role in metabolic syndrome: mendelian randomisation study
NJ Timpson et al.
LANCET (2005)
The druggable genome: an update
AP Russ et al.
DRUG DISCOVERY TODAY (2005)
Towards a proteome-scale map of the human protein-protein interaction network
JF Rual et al.
NATURE (2005)
Proteomic and metabolomic analyses of atherosclerotic vessels from apolipoprotein E-deficient mice reveal alterations in inflammation, oxidative stress, and energy metabolism
M Mayr et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2005)
The druggable genome
AL Hopkins et al.
NATURE REVIEWS DRUG DISCOVERY (2002)
Hierarchical organization of modularity in metabolic networks
E Ravasz et al.
SCIENCE (2002)
Genetic dissection of transcriptional regulation in budding yeast
RB Brem et al.
SCIENCE (2002)
Metabolic control analysis in drug discovery and disease
M Cascante et al.
NATURE BIOTECHNOLOGY (2002)