期刊
NATURE MEDICINE
卷 27, 期 1, 页码 174-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41591-020-1142-7
关键词
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资金
- Institute for Basic Science [IBS-R015-D1]
- National Research Foundation of Korea [2019R1C1C1004512, 2018H1A2A1059844]
- Ministry of Science and ICT, Korea [18-BR-03, 2019-0-01367-BabyMind]
- National Institutes of Health [R01DA035484, R01MH076136]
- Ministry of Science & ICT (MSIT), Republic of Korea [18-BR-03] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2019R1C1C1004512, 2018H1A2A1059844] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study identified a brain biomarker for sustained pain, which showed high sensitivity and specificity to tonic pain and clinical pain. The functional magnetic resonance imaging connectivity pattern of tonic experimental orofacial pain can be used as a quantitative and unbiased biomarker of clinical pain.
Sustained pain is a major characteristic of clinical pain disorders, but it is difficult to assess in isolation from co-occurring cognitive and emotional features in patients. In this study, we developed a functional magnetic resonance imaging signature based on whole-brain functional connectivity that tracks experimentally induced tonic pain intensity and tested its sensitivity, specificity and generalizability to clinical pain across six studies (total n = 334). The signature displayed high sensitivity and specificity to tonic pain across three independent studies of orofacial tonic pain and aversive taste. It also predicted clinical pain severity and classified patients versus controls in two independent studies of clinical low back pain. Tonic and clinical pain showed similar network-level representations, particularly in somatomotor, frontoparietal and dorsal attention networks. These patterns were distinct from representations of experimental phasic pain. This study identified a brain biomarker for sustained pain with high potential for clinical translation. The functional magnetic resonance imaging connectivity pattern of tonic experimental orofacial pain can be used as a quantitative and unbiased biomarker of clinical pain.
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