LCK senses asparagine for T cell activation

Amino acids are critical nutrients that contribute to metabolic and signalling pathways required to meet energy and biosynthetic demands in T cells. A new study now demonstrates that LCK can sense intracellular asparagine to support T cell receptor-mediated CD8(+) T cell activation and effector responses to pathogens and tumours.

Automated summary

Amino acids are essential for T cells to meet their metabolic and biosynthetic demands, and a recent study has shown that LCK can sense intracellular asparagine to support T cell receptor-mediated CD8(+) T cell activation.