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Phase separation in plant miRNA processing

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NATURE CELL BIOLOGY
卷 23, 期 1, 页码 5-6

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NATURE RESEARCH
DOI: 10.1038/s41556-020-00614-5

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  1. Howard Hughes Medical Institute Funding Source: Medline

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Nuclear dicing bodies in plants are now understood as liquid-liquid phase-separated condensates driven by intrinsically disordered regions of the Dicing component SERRATE, which play a role in both phase separation and miRNA processing.
Nuclear dicing bodies were discovered in plants as subcellular droplets of a component of the Dicing complex, which is involved in microRNA production. Now they are revealed to be liquid-liquid phase-separated condensates with intrinsically disordered regions of the Dicing component SERRATE driving both phase separation and miRNA processing.

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