4.4 Article

A new xanthostatin analogue from the marine sponge-associated actinomycete Streptomyces sp. SCSIO 40064

期刊

NATURAL PRODUCT RESEARCH
卷 36, 期 14, 页码 3529-3537

出版社

TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2020.1867131

关键词

xanthostatin B; isobutyryl hexapeptide; marine sponge-associated actinomycete; α -glucosidase inhibitory activity

资金

  1. Chinese Academy of Sciences [XDA13020302, QYZDJ-SSW-DQC004]
  2. National Natural Science Foundation of China [31630004, 41911530078]
  3. Guangdong Province Foundation [2019B030302004]

向作者/读者索取更多资源

A new cyclo-heptadepsipeptide xanthostatin B was isolated from marine sponge derived Streptomyces sp. SCSIO 40064, along with four other compounds. Their structures were elucidated through spectroscopic data analyses and literature comparison. Compound 5 exhibited inhibitory activity against alpha-glucosidase.
A new cyclo-heptadepsipeptide xanthostatin B (1), together with isobutyryl hexapeptide (2), xanthostatin (3), TXS-1 (4) and TXS-2 (5), were isolated from the marine sponge derived Streptomyces sp. SCSIO 40064. The structures were elucidated by comprehensive spectroscopic data analyses and comparison with the literatures. The D-Val unit in 1 was assigned by Marfey's method. The absolute configuration of 4 was determined by X-ray crystallographic analysis. Compounds 1-5 were evaluated for the inhibitory activities against four pharmaceutical targets and six antibacterial indicator strains. Compound 5 displayed alpha-glucosidase inhibitory activity with IC50 value of 18.67 +/- 1.27 mu M.

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