期刊
NATURAL PRODUCT COMMUNICATIONS
卷 16, 期 1, 页码 -出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/1934578X20987095
关键词
chemical activators; Nrf2; nonalcoholic fatty liver disease; ARE
资金
- Zhejiang Provincial Natural Science Foundation-Zhejiang Pharmaceutical Society Joint Fund [LYY18H280004, LY17H290007]
- Special Research Project on Hospital Pharmacy of the Zhejiang Pharmaceutical Association [2018ZYY24]
- National Natural Science Foundation of China [82074186]
- Ten thousand plan-high level talents special support plan of Zhejiang province, China [ZJWR0108035]
This paper summarizes the regulatory mechanism of the Nrf2 signaling pathway and the research progress of Nrf2 activators in NAFLD, highlighting the crucial role of the Nrf2 pathway in cell defense protection.
Nonalcoholic fatty liver disease (NAFLD) is paralleling the insulin resistance andobesity epidemic and is regarded as liver metabolic syndrome, and its prevalence rate is increasing rapidly. The best explanation forthe occurrence and development of NAFLD is the multiple hit hypothesisinstead of the two-hit hypothesis. At present, NAFLD therapies are limited. Thenuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway is a keypathway in oxidative stress. Its downstream proteins/enzymes are regulated. Metabolic enzymes and antioxidant proteins/enzymes play a vital rolein cell defense protection and have attracted attention in the field of antioxidant research in recent years. Thispaper summarizes the regulatory mechanism of the Nrf2 signaling pathway and the research progress of Nrf2 activators in NAFLD to provide guidance for NAFLD therapy in the future.
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