期刊
NANOMEDICINE
卷 15, 期 30, 页码 2901-2916出版社
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2020-0188
关键词
core size; molecular imaging; MRI; nanobubble; prostate cancer; PSMA; ultrasound
资金
- National Natural Science Foundation of China [81671708, 81271595, 81572999, 81771839, 81773272]
- Shanghai Shen Kang Hospital Development Center Research Project [16CR3092B]
- Fund of Shanghai Jiaotong University [YG2014ZD04]
Aim: To design MRI/ultrasound (US) dual modality imaging probes with optimized size for prostate cancer imaging by targeting prostate-specific membrane antigen (PSMA). Materials & methods: The PSMA-targeting polypeptide-nanobubbles (PP-NBs) with core size of 400 and 700 nm were fabricated and evaluated. Results: With excellent physical property and specificity, PP-NBs of both core size could image PSMA expression in prostate cancer xenografts. Particularly, 400 nm PP-NBs generated higher PSMA-specific MRI/US dual modality contrast enhancement than 700 nm PP-NBs in correlation with histopathologic findings. Conclusion: Benefit from the smaller core size, 400 nm PP-NBs had higher permeability and specificity than 700 nm PP-NBs, hence producing better PSMA-specific MRI/US dual modality imaging.
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