期刊
NANO TODAY
卷 35, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2020.100970
关键词
EPR effect; Ex vivo perfusion; Anticancer nanomedicine; X-ray computed tomography; Cancer therapy
资金
- National Natural Science Foundation of China [21620102005, 51933006, 51603231, 51773099, 51473044]
- National Key Research and Development Programs of China [2018YFA0209700]
- State Key Laboratory of Medicinal Chemical Biology, Nankai University [2019016]
The enhanced permeability and retention (EPR) effect in human solid tumors is being increasingly questioned due to the failure of many nanomedicines in their clinical translation. Herein, we developed an ex vivo perfusion model for real-time investigation of the EPR effect in human renal tumors via X-ray computed tomography (CT), proving the EPR in human solid tumors and correlating the EPR effect in human tumors with that in animal models. Unexpectedly, more than 87 % of human renal tumors displayed a considerable EPR effect, which yet showed significant diversity and heterogeneity in different patients. For the first time, we unraveled that the EPR effect in renal tumors was positively correlated with the tumor size, and tumors from male patients exhibited a significantly higher EPR effect. This ex vivo model provides an efficient strategy for investigating the EPR effect in human tumors. Our results may provide a theoretical basis for the development of anticancer nanomedicines in the future. (C) 2020 Elsevier Ltd. All rights reserved.
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