期刊
NANO TODAY
卷 35, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.nantod.2020.100984
关键词
Diabetes; Microneedle; Glucose-responsive; Colloidal crystal; Colorimetric sensor
资金
- National Science Foundation [1708620]
- American Diabetes Association [1-15-ACE-21]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1708620] Funding Source: National Science Foundation
Blood glucose monitoring is a daily routine of people with type 1 or advanced type 2 diabetes. Efforts on minimizing invasiveness, improving portability, and enhancing sustainability of the existing glucose monitoring devices are demanding for elevating patient compliance. Here, we describe a minimally invasive colloidal crystal microneedle (MN) patch for naked-eye glucose monitoring. The glucose-responsive colloidal crystal (GCC)-MN is designed with a polymeric core to mechanically support a shell of GCC for glucose sensing and reporting. The GCC-MN patch could translate the glucose concentrations into naked-eye distinguishable color changes within 5 min, and such glucose responsiveness is reversible. Demonstrated in a type 1 diabetic mouse model, the interstitial fluid extraction, glucose sensing, and resulting glucose-relevant color display procedures are simultaneously achieved with this GCC-MN patch. Published by Elsevier Ltd.
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