期刊
MOVEMENT DISORDERS
卷 36, 期 6, 页码 1440-1445出版社
WILEY
DOI: 10.1002/mds.28502
关键词
essential tremor; cerebellum; climbing fiber; Purkinje cell; pathology
资金
- National Institutes of Health, National Institute of Neurological Disorders and Stroke (NINDS) [R01 NS094607, R01 NS085136, R01 NS073872, R01 NS088257]
- Claire O'Neil Essential Tremor Research Fund (Yale University)
- National Institutes of Health, NINDS [R01 NS085136, R01 NS088257]
- Ministry of Science and Technology in Taiwan [MOST 104-2314-B-002-076-MY3, MOST 107-2321-B-002-020, MOST 108-2321-B-002-011, MOST 108-2321-B-002-059-MY2]
- National Taiwan University Hospital [105-N3227, 108-039]
- Yin-Lin branch of the hospital [NTUHYL104.N007]
- National Institutes of Health (NINDS) [R01 NS104423, R01 NS118179, R03 NS114871]
- Louis V. Gerstner Jr. Scholar Award
- National Ataxia Foundation
- Parkinson's Foundation
- International Essential Tremor Foundation
- Brain Research Foundation
This study found that patients with essential tremor have an increased number of climbing fiber crossings on Purkinje cell dendrites, potentially contributing to abnormal CF wiring and a positive correlation with tremor severity.
Background Climbing fibers (CFs) innervate Purkinje cells (PCs) with 1:1 relationship to ensure proper cerebellar function. Although CFs abnormally extend into the parallel fiber domain of PC dendrites in essential tremor (ET), the architecture of CFs in relation to PCs has yet to be investigated in detail. Objective The aim of this work was to study the architecture of CFs in relation to PCs in ET. Methods The number of PC somas and PC dendrites that a single CF crossed was quantified in the postmortem cerebellum of 15 ET cases and 15 control cases. Results In ET, CFs crossed a greater number of PC somas and PC dendrites than in control cases, raising the possibility that there is abnormal CF wiring onto the PCs. Interestingly, the increase in CF-PC crossings positively correlated with tremor severity. Conclusions Patients with ET have increased CF crossings on PC dendrites. This abnormal architectural arrangement may contribute to synchronous brain activity and tremor. (c) 2021 International Parkinson and Movement Disorder Society
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