期刊
MOVEMENT DISORDERS
卷 36, 期 1, 页码 25-36出版社
WILEY
DOI: 10.1002/mds.28411
关键词
immune; LRRK2; gene by environment; MHCII; inflammation
资金
- Michael J. Fox Foundation for Parkinson's Research
- Parkinson's Foundation
- Emory University School of Medicine Movement Disorders Center
- Udall Center for Excellence in Parkinson's Research
- National Institutes of Health [1R01NS092122, 1RF1AG051514, 1RF1AG057247, T32-GM08605, 1R01NS064934, P50NS108675, R33NS097643]
- DFG (Cluster of Excellence, Precision Medicine in Chronic Inflammation)
- DFG [FOR 2488]
Idiopathic Parkinson's disease is characterized by varied symptoms and progression, with genetic and environmental factors believed to play a significant role in its pathogenesis. Researchers suggest that environmental factors increase iPD risk through the immune system, and the role of PD risk genes in immune cells is worth investigating.
Idiopathic Parkinson's disease (iPD) is a movement disorder characterized by the degeneration of dopaminergic neurons and aggregation of the protein alpha-synuclein. Patients with iPD vary in age of symptom onset, rate of progression, severity of motor and non-motor symptoms, and extent of central and peripheral inflammation. Genetic and environmental factors are believed to act synergistically in iPD pathogenesis. We propose that environmental factors (pesticides and infections) increase the risk for iPD via the immune system and that the role of PD risk genes in immune cells is worthy of investigation. This review highlights the major PD-relevant genes expressed in immune cells and key environmental factors that activate immune cells and, alone or in combination with other factors, may contribute to iPD pathogenesis. By reviewing these interactions, we seek to enable the future development of immunomodulatory approaches to prevent or delay onset of iPD. (c) 2020 International Parkinson and Movement Disorder Society
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