期刊
MOLECULES
卷 26, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/molecules26020367
关键词
diabetes; diabetic nephropathy; ginseng; GS-E3D
资金
- Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry, and Fisheries (IPET) through the Export Promotion Technology Development Program - Ministry of Agriculture, Food, and Rural Affairs [315049-05-2CG000]
- National Research Foundation of Korea (NRF) - Korea government (MEST) [NRF-2019R1A2C1008773]
The study demonstrates that pectin-lyase-modified ginseng (GS-E3D) has a significant protective effect on diabetes-induced renal dysfunction, reducing oxidative stress and cell apoptosis through its antioxidative and antiapoptotic activities. These results provide valuable insights for patients seeking dietary supplements for diabetes-related renal dysfunction.
Diabetes increases the incidence rate of chronic renal disease. Pectin-lyase-modified ginseng (GS-E3D), with enhanced ginsenoside Rd content, has been newly developed. In this study, renal protective roles of GS-E3D in type-2 diabetic db/db mice were investigated. The generation of reactive oxygen species (ROS) induced by high glucose (25 mM) was reduced by ES-E3D (75%) and ginsenoside Rd (60%). Diabetic db/db mice received 100 or 250 mg/kg/day of GS-E3D daily via oral gavage for 6 weeks. Albuminuria and urinary 8-hydroxy-2 '-deoxyguanosine (8-OhdG, an oxidative stress marker) levels were increased in db/db mice and the levels recovered after GS-E3D treatment. In renal tissues, TUNEL-positive cells were decreased after GS-E3D treatment, and the increased apoptosis-related protein expressions were restored after GS-E3D treatment. Therefore, GS-E3D has a potent protective role in diabetes-induced renal dysfunction through antioxidative and antiapoptotic activities. These results may help patients to select a dietary supplement for diabetes when experiencing renal dysfunction.
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