期刊
MOLECULES
卷 26, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/molecules26020355
关键词
organocatalysis; ionic liquids; ene-type reactions; tertiary alcohols; solvent engineering; asymmetric catalysis
资金
- Spanish MINECO [CTQ2016-76908-C2-1-P, CTQ201676908-C2-2-P]
- European FEDER funds
- Junta de Andalucia [P18-FR-3531]
Room temperature ionic liquids (RTILs) have shown positive effects in organic catalysis, enhancing catalyst activity, lowering reaction temperatures, and improving yields and enantioselectivity.
Room temperature ionic liquids (RTILs) have been widely used as (co)solvents in several catalytic processes modifying, in most of the cases, the catalyst activity and/or the selectivity for the studied reactions. However, there are just a few examples of their use in hydrogen bonding organocatalysis. In this paper, we show the positive effect of a set of imidazole-based ionic liquids ([bmim]BF4 and [hmim]PF6) in the enantioselective addition of formaldehyde tert-butylhydrazone to prochiral alpha-keto esters catalyzed by a sugar-based chiral thiourea. Reactions performed in the presence of low percentages of RTILs led to an increase of the catalyst activity, thereby making possible to work at lower temperatures. Thus, the chiral tert-butyl azomethyl tertiary alcohols could be obtained with moderate to good conversions and higher enantioselectivities for most of the studied substrates when using up to 30 vol% of [hmim]PF6 as a cosolvent in processes performed in toluene.
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