期刊
MOLECULES
卷 25, 期 22, 页码 -出版社
MDPI
DOI: 10.3390/molecules25225354
关键词
pyrazolo[3; 4-d]pyrimidines; kinase inhibitors; antimicrobials; β -lactam antibiotics
资金
- Engineering and Physical Sciences Council [EP/N50970X/1, EP/N03371X/1]
- Royal Society [WM150086]
Pyrazolo[3,4-d]pyrimidines represent an important class of heterocyclic compounds well-known for their anticancer activity exerted by the inhibition of eukaryotic protein kinases. Recently, pyrazolo[3,4-d]pyrimidines have become increasingly attractive for their potential antimicrobial properties. Here, we explored the activity of a library of in-house pyrazolo[3,4-d]pyrimidines, targeting human protein kinases, against Staphylococcus aureus and Escherichia coli and their interaction with ampicillin and kanamycin, representing important classes of clinically used antibiotics. Our results represent a first step towards the potential application of dual active pyrazolo[3,4-d]pyrimidine kinase inhibitors in the prevention and treatment of bacterial infections in cancer patients.
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