期刊
MOLECULES
卷 26, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/molecules26030624
关键词
thiazole; bisthiazole; synthesis; derivatives; biological activity
Thiazole, a key heteroaromatic ring, is a crucial scaffold in many synthetic compounds, with diverse pharmacological activities found in clinically approved molecules. Numerous biologically active thiazole and bisthiazole derivatives have been reported, encouraging further research on thiazole-containing drugs.
Thiazole, a five-membered heteroaromatic ring, is an important scaffold of a large number of synthetic compounds. Its diverse pharmacological activity is reflected in many clinically approved thiazole-containing molecules, with an extensive range of biological activities, such as antibacterial, antifungal, antiviral, antihelmintic, antitumor, and anti-inflammatory effects. Due to its significance in the field of medicinal chemistry, numerous biologically active thiazole and bisthiazole derivatives have been reported in the scientific literature. The current review provides an overview of different methods for the synthesis of thiazole and bisthiazole derivatives and describes various compounds bearing a thiazole and bisthiazole moiety possessing antibacterial, antifungal, antiprotozoal, and antitumor activity, encouraging further research on the discovery of thiazole-containing drugs.
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