期刊
MOLECULES
卷 26, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/molecules26030620
关键词
wound healing; in vivo; Vaseline; immunological assay; histopathology
资金
- Ministry of Research and Innovation CNCSIS-UEFISCDI [PN-III-P1.1.1-TE-2019-1138]
- New National Excellence Program of the Ministry for Innovation and Technology [UNKP-20-5-SZTE-657]
- Janos Bolyai Research Scholarship of the Hungarian Academy of Science
The study showed that bioactive glass with spherical gold nanocages in Vaseline ointments can enhance skin healing and regeneration in rats, with great antibacterial activity to prevent bacterial infections. The incorporation of silver stabilized spherical gold nanocages influenced the wound healing process, leading to complete skin regeneration after two weeks in all groups of rats.
The silver content of the skin regeneration ointments can influence its regeneration process but in the meantime, it can take the benefit of the antibacterial properties of silver by avoiding the bacterial infection of an open wound. In the current study, the skin healing and regeneration capacity of bioactive glass with spherical gold nanocages (BGAuIND) in the Vaseline ointments were evaluated in vivo comparing the bioactive glass (BG)-Vaseline and bioactive glass with spherical gold (BGAuSP)-Vaseline ointments. Spherical gold nanocages are stabilized with silver and as a consequence the BGAuIND exhibits great antibacterial activity. Histological examination of the cutaneous tissue performed on day 8 indicates a more advanced regeneration process in rats treated with BGAuSP-Vaseline. The histopathological examination also confirms the results obtained after 11 days post-intervention, when the skin is completely regenerated at rats treated with BGAuSP-Vaseline compared with the others groups where the healing was incomplete. This result is also confirmed by the macroscopic images of the evolution of wounds healing. As expected, the silver content influences the wound healing process but after two weeks, for all of the post-interventional trials from the groups of rats, the skin healing was completely.
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