期刊
MOLECULES
卷 26, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/molecules26020453
关键词
polyphenols; epigallocatechin-3-O-gallate; chlorogenic acid; resveratrol; curcumin; obesity; reactive oxygen species; 5′ -AMP-activated protein kinase; nuclear factor-κ B; randomized controlled trial
Green tea, coffee, wine, and curry have beneficial effects on human health, such as anti-obesity, anti-cancer, anti-diabetic, and neuroprotective properties, attributed to polyphenols like epigallocatechin gallate and resveratrol. These polyphenols have conflicting actions as both anti-oxidants and pro-oxidants, potentially modulating enzymes and factors related to health. However, human studies have shown inconsistencies in the effects of these foods on obesity, possibly due to various study factors.
Several epidemiological studies and clinical trials have reported the beneficial effects of green tea, coffee, wine, and curry on human health, with its anti-obesity, anti-cancer, anti-diabetic, and neuroprotective properties. These effects, which have been supported using cell-based and animal studies, are mainly attributed to epigallocatechin gallate found in green tea, chlorogenic acid in coffee, resveratrol in wine, and curcumin in curry. Polyphenols are proposed to function via various mechanisms, the most important of which is related to reactive oxygen species (ROS). These polyphenols exert conflicting dual actions as anti- and pro-oxidants. Their anti-oxidative actions help scavenge ROS and downregulate nuclear factor-kappa B to produce favorable anti-inflammatory effects. Meanwhile, pro-oxidant actions appear to promote ROS generation leading to the activation of 5 '-AMP-activated protein kinase, which modulates different enzymes and factors with health beneficial roles. Currently, it remains unclear how these polyphenols exert either pro- or anti-oxidant effects. Similarly, several human studies showed no beneficial effects of these foods, and, by extension polyphenols, on obesity. These inconsistencies may be attributed to different confounding study factors. Thus, this review provides a state-of-the-art update on these foods and their principal polyphenol components, with an assumption that it prevents obesity.
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