期刊
MOLECULES
卷 26, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/molecules26030618
关键词
angiotensin II; RAS; cyclic peptides; sarmesin; sartans; mimetics; transdermal delivery; Covid 19; Sars-CoV-2
资金
- General Secretariat for Research and Technology (GSRT)
- Patras Science Park
- Institute for Health and Sport, Victoria University
Angiotensin II is a widely studied hormone that has led to the design and synthesis of non-peptide drugs. These drugs have made breakthroughs in the treatment of hypertension and were widely marketed in the 1990s. Recent studies have found that RAS inhibitors can help resist SARS-CoV-2 infection, maintain homeostasis, and vasodilation.
The octapeptide hormone angiotensin II is one of the most studied peptides with the aim of designing and synthesizing non-peptide mimetics for oral administration. To achieve this, cyclizations at different positions within the peptide molecule has been a useful strategy to define the active conformation. These studies on angiotensin II led to the discovery of Sarmesin, a type II angiotensin II antagonist, and the breakthrough non-peptide mimetic Losartan, the first in a series of sartans marketed as a new generation of anti-hypertensive drugs in the 1990s. Angiotensin II receptor blockers (ARBS) and angiotensin I converting enzyme inhibitors (ACEI) were recently reported to protect hypertensive patients infected with SARS-CoV-2. The renin-angiotensin system (RAS) inhibitors reduce excess angiotensin II and increase antagonist heptapeptides alamandine and aspamandine which counterbalance angiotensin II and maintain homeostasis and vasodilation.
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