期刊
MOLECULAR PSYCHIATRY
卷 26, 期 6, 页码 2663-2676出版社
SPRINGERNATURE
DOI: 10.1038/s41380-020-00985-z
关键词
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资金
- Canada Research Chair in neurodevelopmental disorders
- Jeanne et Jean Louis Levesque Foundation
- Institute for Data Valorization (IVADO) fellowship
- Canadian Institute of Health Research (CIHR)
- Sainte-Justine Foundation
- Merit Scholarship Program for foreign students
- Network of Applied Genetic Medicine fellowships
- chair of the Bettencourt-Schueler foundation
- Brain Canada Multi-Investigator initiative
- Canadian Institutes of Health Research
- Heart and Stroke Foundation of Canada
- Wellcome Trust
- NIH [U01 MH119690, U01 MH119739]
- Calcul Quebec
- Compute Canada
- CIHR [159734]
The study reveals that genomic copy number variants have an impact on intelligence, especially on genes intolerant to haploinsufficiency. However, the effect sizes of duplications remain unclear, and it is unknown if the effect of multigenic CNVs are driven by a few intolerant genes or distributed across tolerant genes.
Genomic copy number variants (CNVs) are routinely identified and reported back to patients with neuropsychiatric disorders, but their quantitative effects on essential traits such as cognitive ability are poorly documented. We have recently shown that the effect size of deletions on cognitive ability can be statistically predicted using measures of intolerance to haploinsufficiency. However, the effect sizes of duplications remain unknown. It is also unknown if the effect of multigenic CNVs are driven by a few genes intolerant to haploinsufficiency or distributed across tolerant genes as well. Here, we identified all CNVs > 50 kilobases in 24,092 individuals from unselected and autism cohorts with assessments of general intelligence. Statistical models used measures of intolerance to haploinsufficiency of genes included in CNVs to predict their effect size on intelligence. Intolerant genes decrease general intelligence by 0.8 and 2.6 points of intelligence quotient when duplicated or deleted, respectively. Effect sizes showed no heterogeneity across cohorts. Validation analyses demonstrated that models could predict CNV effect sizes with 78% accuracy. Data on the inheritance of 27,766 CNVs showed that deletions and duplications with the same effect size on intelligence occur de novo at the same frequency. We estimated that around 10,000 intolerant and tolerant genes negatively affect intelligence when deleted, and less than 2% have large effect sizes. Genes encompassed in CNVs were not enriched in any GOterms but gene regulation and brain expression were GOterms overrepresented in the intolerant subgroup. Such pervasive effects on cognition may be related to emergent properties of the genome not restricted to a limited number of biological pathways.
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