期刊
MOLECULAR NUTRITION & FOOD RESEARCH
卷 65, 期 3, 页码 -出版社
WILEY
DOI: 10.1002/mnfr.202000875
关键词
biomarker; cocoa; coffee; metabolomics; xenobiotics
资金
- Soremartec Italia S.r.l. (Alba, Italy)
This study aimed at evaluating the impact of different patterns of coffee intake on endogenous molecular pathways through untargeted metabolomics analysis, identifying 153 discriminant metabolites related to coffee consumption. The results provide new insights into the metabolic routes by which coffee and coffee-related metabolites may exert effects on human health.
Scope Several studies suggest that regular coffee consumption may help preventing chronic diseases, but the impact of daily intake and the contribution of coffee metabolites in disease prevention are still unclear. The present study aims at evaluating whether and how different patterns of coffee intake (one cup of espresso coffee/day, three cups of espresso coffee/day, and one cup of espresso coffee/day and two cocoa-based products containing coffee two times per day) may impact endogenous molecular pathways. Methods and Results A three-arm, randomized, crossover trial is performed in 21 healthy volunteers who consumed each treatment for one month. Urine samples are collected to perform untargeted metabolomics based on UHPLC-IMS-HRMS. A total of 153 discriminant metabolites are identified. Several molecular features are associated with coffee consumption, while others are linked with different metabolic pathways, such as phenylalanine, tyrosine, energy metabolism, steroid hormone biosynthesis, and arginine biosynthesis and metabolism. Conclusion This information has provided new insights into the metabolic routes by which coffee and coffee-related metabolites may exert effects on human health.
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