4.6 Article

Adiponectin in Cerebrospinal Fluid from Patients Affected by Multiple Sclerosis Is Correlated with the Progression and Severity of Disease

期刊

MOLECULAR NEUROBIOLOGY
卷 58, 期 6, 页码 2663-2670

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SPRINGER
DOI: 10.1007/s12035-021-02287-z

关键词

Adiponectin; HMW oligomers; Multiple sclerosis; Cerebrospinal fluid; Inflammation

资金

  1. Universita degli Studi della Campania Luigi Vanvitelli

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Adiponectin levels in the cerebrospinal fluid were significantly elevated in multiple sclerosis (MS) patients and positively correlated with CSF IgG levels, suggesting a potential relationship with disease severity and prognosis. Changes in the oligomerization profile of adiponectin in CSF from MS patients, with increased high molecular weight and medium molecular weight forms, were also observed.
Adiponectin exerts relevant actions in immunity and is modulated in several disorders, such as multiple sclerosis (MS). In this study, we characterized adiponectin expression and profiles in cerebrospinal fluid (CSF) from MS patients to investigate its potential relationship with the severity and progression of the disease. Total adiponectin in CSF was measured by ELISA in 66 unrelated CSF MS patients and compared with 24 age- and sex-matched controls. Adiponectin oligomer profiles were analysed by Western blotting and FPLC chromatography. Total CSF adiponectin was significantly increased in MS patients compared with controls (9.91 ng/mL vs 6.02 ng/mL) (p < 0.001). Interestingly, CSF adiponectin positively correlated with CSF IgG, and CSF/serum albumin directly correlated with CSF/serum adiponectin. Our data demonstrated that CSF adiponectin predicts a worse prognosis: patients with the progressive form of MS had higher levels compared with the relapsing remitting form; patients with higher EDSS at baseline and a higher MS severity score at 4.5-year follow-up had significantly elevated adiponectin levels with respect to patients with a less severe phenotype. Finally, the adiponectin oligomerization profile was altered in CSF from MS patients, with a significant increase in HMW and MMW. The correlation of CSF adiponectin with the severity and prognosis of MS disease confirmed the role of this adipokine in the inflammatory/immune processes of MS and suggested its use as a complementary tool to assess the severity, progression and prognosis of the disease. Further studies on larger MS cohorts are needed to clarify the contribution of adiponectin to the etiopathogenesis of MS.

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