期刊
MOLECULAR MICROBIOLOGY
卷 115, 期 5, 页码 930-941出版社
WILEY
DOI: 10.1111/mmi.14682
关键词
development; motility; sensing; signaling; trypanosome
资金
- NIAID NIH HHS [R56 AI052348, R21 AI133166, R21 AI142544, R01 AI052348] Funding Source: Medline
- NIGMS NIH HHS [T32 GM008042] Funding Source: Medline
Studying the movement through specific tissues and differentiation stages of various African trypanosomes, as well as the signaling events involved, enhances our understanding of the biological characteristics of these parasites.
Trypanosoma brucei and other African trypanosomes are vector-borne parasites that cause substantial human suffering across sub-Saharan Africa. The T. brucei life cycle is punctuated by numerous developmental stages, each occurring in a specific environmental niche and characterized by a unique morphology, metabolism, surface protein coat, and gene expression profile. The environmental cues and signaling pathways that drive transitions between these stages remain incompletely understood. Recent studies have started to fill this gap in knowledge. Likewise, several new studies have expanded our understanding of parasite movement through specific tissues and the parasite's ability to alter movement in response to external cues. Life cycle stage differentiation and motility are intimately integrated phenomena, as parasites must be at the right place (i.e., within a specific environmental milieu) at the right time (i.e., when they are appropriately staged and preadapted for perceiving and responding to signals) in order to complete their life cycle. In this review, we highlight some of the recent work that has transformed our understanding of signaling events that control parasite differentiation and motility. Increased knowledge of T. brucei environmental sensing and signal transduction advances our understanding of parasite biology and may direct prospective chemotherapeutic and transmission blockade strategies that are critical to eradication efforts.
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