期刊
MOLECULAR MICROBIOLOGY
卷 115, 期 5, 页码 891-900出版社
WILEY
DOI: 10.1111/mmi.14652
关键词
epigenetics; gene expression; malaria; metabolites; nutrient sensing
资金
- National Institute of Allergy and Infectious Diseases [5R01AI38551]
Malaria caused by Plasmodium parasites is a life-threatening infectious disease, and Plasmodium falciparum in particular can sense nutrient levels in the blood-stage to drive changes in gene expression affecting proliferation, antigenic variation, and transmission.
Malaria is one of the most life-threatening infectious diseases worldwide, caused by infection of humans with parasites of the genus Plasmodium. The complex life cycle of Plasmodium parasites is shared between two hosts, with infection of multiple cell types, and the parasite needs to adapt for survival and transmission through significantly different metabolic environments. Within the blood-stage alone, parasites encounter changing levels of key nutrients, including sugars, amino acids, and lipids, due to differences in host dietary nutrition, cellular tropism, and pathogenesis. In this review, we consider the mechanisms that the most lethal of malaria parasites, Plasmodium falciparum, uses to sense nutrient levels and elicit changes in gene expression during blood-stage infections. These changes are brought about by several metabolic intermediates and their corresponding sensor proteins. Sensing of distinct nutritional signals can drive P. falciparum to alter the key blood-stage processes of proliferation, antigenic variation, and transmission.
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