Role of long non-coding RNA H19 in therapy resistance of digestive system cancers

Digestive system cancers are associated with high morbidity and mortality. Chemotherapy and radiotherapy are the main treatment modalities for these cancers. However, the development of therapy resistance leads to high rates of tumor recurrence and metastasis, resulting in dismal prognosis. Long non-coding RNA (LncRNA) H19, one of the most intriguing non-coding RNAs, has been shown to play a key role in the development and therapy resistance of various digestive system cancers (including hepatocellular carcinoma, colorectal cancer, pancreatic ductal adenocarcinoma, esophageal carcinoma, gastric cancer, and biliary system cancer) by regulating the abnormal expression of genes. In this review, we discuss the potential mechanisms of LncRNA H19 related therapy resistance in the context of digestive system cancers. LncRNA H19 is a potential novel therapeutic target for amelioration of cancer therapy resistance.

Automated summary

The resistance to therapy in digestive system cancers is closely associated with Long non-coding RNA (LncRNA) H19, which regulates the abnormal expression of genes and plays a key role in the development and treatment resistance of various digestive system cancers. Identifying and targeting LncRNA H19 could be a potential novel therapeutic approach to improve cancer therapy resistance.