期刊
MOLECULAR BIOLOGY REPORTS
卷 48, 期 1, 页码 961-967出版社
SPRINGER
DOI: 10.1007/s11033-020-06050-w
关键词
Exosome; microRNAs; Biomarkers; Non-communicable disease
资金
- Consejo Nacional de Ciencia y Tecnologia (CONACYT), Mexico [417965]
- Consejo Nacional de Ciencia y Tecnologia (CONACYT) [FOSEC-SS/IMSS/ISSSTE A3-S-43439]
Exosomes, particularly the miRs within them, have the potential to serve as non-invasive biomarkers for the diagnosis and prognosis of various diseases, making them valuable tools for disease management and early detection.
Exosomes are vesicles, ranging of 30-150 nm in diameter, which are released by different cell types into the extracellular space. Exosomes are capable of transporting several biomolecules such as proteins, lipids, DNA, mRNA, and non-coding RNA, including microRNAs (miRs). miRs signatures have been linked to the development of non-communicable diseases and their classification into various subtypes and/or stages. Interestingly, the miRs contained in exosomes (exomiRs) are suitable candidates as non-invasive biomarkers due to their stability in body fluids and harsh conditions, as well as they are considered critical players involved in intercellular communication; so that they can be a promising diagnostic tool for several diseases. Besides, exomiRs allow discrimination between different stages of the disease and could be a valuable strategy for the early detection of several pathologies in a non-invasive approach. This review aims to describe exomiRs present in biologic fluids that can be used as a tool for the diagnosis and prognosis of non-communicable diseases such as cancer, cardiovascular, kidney, and neurodegenerative disease.
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