期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 518, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2020.110998
关键词
Schwann cell precursors; Chromaffin cells; Oxygen-sensing; Neuroblastoma; Paraganglioma; Pheochromocytoma
资金
- Swedish Research Council grant (Vetenskapsradet, VR)
- ERC Consolidator grant STEMMING-FROM-NERVE [N647844]
- Paradifference Foundation
- Bertil Hallsten Research Foundation
- Novo Nordisk Foundation (Postdoc fellowship in Endocrinology and Metabolism at International Elite Environments) [NNF17OC0026874]
- Stiftelsen Riksbankens Jubileumsfond (Erik Ronnbergs fond stipend)
The mammalian adrenal gland is composed of two main components; the catecholaminergic neural crest-derived medulla, found in the center of the gland, and the mesoderm-derived cortex producing steroidogenic hormones. The medulla is composed of neuroendocrine chromaffin cells with oxygen-sensing properties and is dependent on tissue interactions with the overlying cortex, both during development and in adulthood. Other relevant organs include the Zuckerkandl organ containing extra-adrenal chromaffin cells, and carotid oxygen-sensing bodies containing glomus cells. Chromaffin and glomus cells reveal a number of important similarities and are derived from the multipotent nerve-associated descendants of the neural crest, or Schwann cell precursors. Abnormalities in complex developmental processes during differentiation of nerve-associated and other progenitors into chromaffin and oxygen-sensing populations may result in different subtypes of paraganglioma, neuroblastoma and pheochromocytoma. Here, we summarize recent findings explaining the development of chromaffin and oxygen-sensing cells, as well as the potential mechanisms driving neuroendocrine tumor initiation.
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