期刊
MOLECULAR AND CELLULAR ENDOCRINOLOGY
卷 518, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.mce.2020.110997
关键词
Hypothalamic-pituitary axis; Endocrine-disrupting chemicals; Neuroendocrine action; Hypothalamus; Pituitary; Toxicological effects
资金
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-Brasil/Fundacao de Amparo a Pesquisa e Inovacao do Espirito Santo (CNPq/FAPES) [572/2018]
- FAPES [179/2017, 72630477/2014]
- CNPq [304724/2017-3]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil (CAPES) [00]
The hypothalamic-pituitary axis (HP axis) plays a critical and integrative role in the endocrine system control to maintain homeostasis. The HP axis is responsible for the hormonal events necessary to regulate the thyroid, adrenal glands, gonads, somatic growth, among other functions. Endocrine-disrupting chemicals (EDCs) are a worldwide public health concern. There is growing evidence that exposure to EDCs such as bisphenol A (BPA), some phthalates, polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs) and biphenyls (PBBs), dichlorodiphenyltrichloroethane (DDT), tributyltin (TBT), and atrazine (ATR), is associated with HP axis abnormalities. EDCs act on hormone receptors and their downstream signaling pathways and can interfere with hormone synthesis, metabolism, and actions. Because the HP axis function is particularly sensitive to endogenous hormonal changes, disruptions by EDCs can alter HP axis proper function, leading to important endocrine irregularities. Here, we review the evidence that EDCs could directly affect the mammalian HP axis function.
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