Thermosensation involving thermo-TRPs

The transient receptor potential (TRP) channels constitute a superfamily of large ion channels that are activated by a wide range of chemical, mechanical and thermal stimuli. TRP channels with temperature sensitivity are called thermo-TRPs. They are involved in diverse physiological functions through their detection of external environmental temperature and internal body temperature. Each thermo-TRP has its own characteristic temperature threshold for activation. As a group, they cover temperatures ranging from cold to nociceptive high temperatures. Recently, many studies have identified the functions of thermo-TRPs residing in deep organs where they are exposed to body temperature. Importantly, temperature thresholds of thermo-TRPs can be regulated by physiological factors enabling their function at relatively constant body temperature. Moreover, several thermo-TRPs are reportedly engaged in body temperature regulation. This review will summarize the current understanding of thermo-TRPs, including their roles in thermosensation and functional regulation of physiological responses at body temperature and the regulation of body temperature.

Automated summary

Transient receptor potential (TRP) channels are large ion channels that are activated by various chemical, mechanical, and thermal stimuli. Among them, thermo-TRP channels are sensitive to temperature and play roles in physiological functions related to thermosensation and temperature regulation. These channels have distinct temperature thresholds and can be regulated by physiological factors, allowing them to function effectively at body temperature.