期刊
MICROPOROUS AND MESOPOROUS MATERIALS
卷 310, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.micromeso.2020.110593
关键词
Mesoporous silica nanoparticles; Internalization; Toxicity; Biocompatibility
类别
资金
- Spanish Government (MCUI/AEI/FEDER, UE) [RTI2018-100910-B-C41]
- ISCIII [PI18/01219]
- Generalitat Valenciana [PROMETEO/2018/024, ACIF/2016/030]
- CIBER-BBN [CB07/01/2012]
- CIBER-ONC [CB16/12/00481]
Mesoporous silica nanoparticles (MSNs) are efficiently internalized by human cells, with uptake mechanisms differing among cell types and particles. These biocompatible materials do not induce ROS/RNS production, nor affect mitochondrial membrane potential or cell cycle within cells.
We report herein an evaluation of the effect of several mesoporous silica nanoparticles (MSNs) on the cellular uptake and in vitro cytotoxicity in human cells. Bare MSNs and MSNs functionalized with polyethylene glycol or hyaluronic acid are employed to evaluate uptake efficiency and mechanisms of endocytosis in cancer (MDA-MB-231) and non-cancer (MCF10A) cells. Moreover, changes in viability, cell cycle, oxidative stress, and mitochondrial membrane potential are evaluated. Our results confirm that MSNs are internalized efficiently by human cells and that uptake mechanisms differ for cell types and particles. We also confirm that MSNs are biocompatible materials that do not induce ROS/RNS production, nor changes on mitochondrial membrane potential or cell cycle.
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