期刊
MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS
卷 85, 期 1, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/MMBR.00151-20
关键词
signaling; Pseudomonas aeruginosa; chemosensory pathway; chemotaxis
类别
资金
- FEDER funds
- Fondo Social Europeo
- Spanish Ministry for Science and Innovation [PID2019-103972GA-I00]
- Spanish Ministry of Economy and Competitiveness [BIO2016-74875-P, BIO2016-76779-P]
Bacteria have evolved various signal transduction mechanisms, with chemosensory pathways being among the most complex in Pseudomonas aeruginosa, regulating key functions and involving numerous chemoreceptors.
Bacteria have evolved a variety of signal transduction mechanisms that generate different outputs in response to external stimuli. Chemosensory pathways are widespread in bacteria and are among the most complex signaling mechanisms, requiring the participation of at least six proteins. These pathways mediate flagellar chemotaxis, in addition to controlling alternative functions such as second messenger levels or twitching motility. The human pathogen Pseudomonas aeruginosa has four different chemosensory pathways that carry out different functions and are stimulated by signal binding to 26 chemoreceptors. Recent research employing a diverse range of experimental approaches has advanced enormously our knowledge on these four pathways, establishing P. aeruginosa as a primary model organism in this field. In the first part of this article, we review data on the function and physiological relevance of chemosensory pathways as well as their involvement in virulence, whereas the different transcriptional and posttranscriptional regulatory mechanisms that govern pathway function are summarized in the second part. The information presented will be of help to advance the understanding of pathway function in other organisms.
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