期刊
MICROBIAL PATHOGENESIS
卷 150, 期 -, 页码 -出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.micpath.2020.104697
关键词
Coexistence; Tet(X5); NDM-3; Tigecycline resistance; Carbapenem resistance; Acinetobacter indicus
资金
- National Natural Science Foundation of China [31830001, 31700007]
- State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products [2010DS700124-ZZ1905, ZZ1703]
- National Key Research and Development Program of China [2017YFD0500202]
- Key Research and Development Program of Zhejiang Province [2020C02031]
A tigecycline- and carbapenem-resistant Acinetobacter indicus strain of duck origin, co-producing Tet(X5) and NDM-3, was reported in this study, highlighting the importance of antimicrobial resistance surveillance in poultry production.
Tigecycline and carbapenem are last-resort antibiotics for serious infections caused by pathogens with multi-drug resistance (MDR). Whereas, bacterial pathogens with co-resistance to tigecycline and carbapenem are poorly addressed. Here we report a tigecycline- and carbapenem-resistant Acinetobacter indicus strain HY20 of duck origin, which co-produces Tet(X5) and NDM-3. Tet(X5) is harbored by a novel plasmid pAI01 (116,992 bp long), which carries 10 antimicrobial resistance genes (AMRs), and heavy metal resistance system cobalt-zinc-cadmium (czc) gene cluster. Unlike that tet(X5) is located in the res tet(X5) xerD segment of plasmid, the chromosomal bla(NDM-3) is flanked by insertion ISAba125. Collectively, our result represents an example of co-carriage of tet(X5) and bla(NDM-3), heightening the importance of AMR surveillance needed in poultry production.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据
分享论文
