期刊
MEDICINAL RESEARCH REVIEWS
卷 41, 期 3, 页码 1291-1336出版社
WILEY
DOI: 10.1002/med.21761
关键词
natural products; STAT; stem cells; tumorigenesis
资金
- Department of Biotechnology (DBT), Government of India under its Ramalingaswami Fellowship [BT/RLF/Re-entry/24/2014]
- Science & Engineering Research Board (SERB), DST, Government of India [ECR/2016/001519]
- NUHS Seed grant
- National Medical Research Council of Singapore (NMRC OF-IRG)
- Singapore Ministry of Education (MOE Tier 2)
- National Research Foundation Singapore
- Singapore Ministry of Education under its Research Centers of Excellence initiative to Cancer Science Institute of Singapore
- National University of Singapore
The review discusses the regulation of STAT3 signaling and its association with the development of both solid and hematological malignancies. It also mentions various ways to target oncogenic STAT3 signaling using small molecules derived from natural products.
Signal transducer and activator of transcription 3 (STAT3) is one of the crucial transcription factors, responsible for regulating cellular proliferation, cellular differentiation, migration, programmed cell death, inflammatory response, angiogenesis, and immune activation. In this review, we have discussed the classical regulation of STAT3 via diverse growth factors, cytokines, G-protein-coupled receptors, as well as toll-like receptors. We have also highlighted the potential role of noncoding RNAs in regulating STAT3 signaling. However, the deregulation of STAT3 signaling has been found to be associated with the initiation and progression of both solid and hematological malignancies. Additionally, hyperactivation of STAT3 signaling can maintain the cancer stem cell phenotype by modulating the tumor microenvironment, cellular metabolism, and immune responses to favor drug resistance and metastasis. Finally, we have also discussed several plausible ways to target oncogenic STAT3 signaling using various small molecules derived from natural products.
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