相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。In vitro and in vivo induction of fetal hemoglobin with a reversible and selective DNMT1 inhibitor
Aidan G. Gilmartin et al.
HAEMATOLOGICA (2021)
Protein Interaction Domains and Post-Translational Modifications: Structural Features and Drug Discovery Applications
Marian Vincenzi et al.
CURRENT MEDICINAL CHEMISTRY (2020)
Combining epigenetic drugs with other therapies for solid tumours - past lessons and future promise
Daphne Morel et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2020)
Bioinspired Nitroalkylation for Selective Protein Modification and Peptide Stapling
Sriram Mahesh et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)
New Promise and Opportunities for Allosteric Kinase Inhibitors
Xiaoyun Lu et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)
Proteolysis-targeting chimeras in drug development: A safety perspective
Kevin Moreau et al.
BRITISH JOURNAL OF PHARMACOLOGY (2020)
Click Chemistry in Proteomic Investigations
Christopher G. Parker et al.
CELL (2020)
Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains
Tamta Arakhamia et al.
CELL (2020)
Role of Post-translational Modifications in Alzheimer's Disease
Madhu Ramesh et al.
CHEMBIOCHEM (2020)
A single-center retrospective cohort analysis of venetoclax in relapsed/refractory multiple myeloma
Swetha Kambhampati et al.
LEUKEMIA & LYMPHOMA (2020)
Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer
Emily J. Faivre et al.
NATURE (2020)
HBO1 is required for the maintenance of leukaemia stem cells
Laura MacPherson et al.
NATURE (2020)
Discovery of a first-in-class EZH2 selective degrader
Anqi Ma et al.
NATURE CHEMICAL BIOLOGY (2020)
FDA approves an inhibitor of a novel ‘epigenetic writer’
Asher Mullard
NATURE REVIEWS DRUG DISCOVERY (2020)
m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer
Huilin Huang et al.
CANCER CELL (2020)
Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity
Linlin Sun et al.
CANCER RESEARCH (2020)
Curing HIV: Seeking to Target and Clear Persistent Infection
David M. Margolis et al.
CELL (2020)
Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion
Zhongya Sun et al.
ADVANCED SCIENCE (2020)
Genetically encoded protein sulfation in mammalian cells
James S. Italia et al.
NATURE CHEMICAL BIOLOGY (2020)
Illustrating human PLD
Lei Zheng et al.
NATURE CHEMICAL BIOLOGY (2020)
MusiteDeep: a deep-learning based webserver for protein post-translational modification site prediction and visualization
Duolin Wang et al.
NUCLEIC ACIDS RESEARCH (2020)
O-GlcNAcase: Emerging Mechanism, Substrate Recognition and Small-Molecule Inhibitors
Ahmed A. Elbatrawy et al.
CHEMMEDCHEM (2020)
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion
Rui Su et al.
CANCER CELL (2020)
A Unified Model for the Function of YTHDF Proteins in Regulating m6A-Modified mRNA
Sara Zaccara et al.
CELL (2020)
Developing bioorthogonal probes to span a spectrum of reactivities
Sean S. Nguyen et al.
NATURE REVIEWS CHEMISTRY (2020)
Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies
Yonghan He et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)
RNA methyltransferase inhibitor reduces AML
Megan Cully
NATURE REVIEWS DRUG DISCOVERY (2020)
Single-particle cryo-EM at atomic resolution
Takanori Nakane et al.
NATURE (2020)
Atomic-resolution protein structure determination by cryo-EM
Ka Man Yip et al.
NATURE (2020)
Covalent inhibition of NSD1 histone methyltransferase
Huang Huang et al.
NATURE CHEMICAL BIOLOGY (2020)
A universal system for digitization and automatic execution of the chemical synthesis literature
S. Hessam M. Mehr et al.
SCIENCE (2020)
Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader
Frances Potjewyd et al.
CELL CHEMICAL BIOLOGY (2020)
On enzymatic remodeling of IgG glycosylation; unique tools with broad applications
Jonathan Sjogren et al.
GLYCOBIOLOGY (2020)
Targeting Glycosylation: A New Road for Cancer Drug Discovery
Ana Filipa Costa et al.
TRENDS IN CANCER (2020)
Integration of network models and evolutionary analysis into high-throughput modeling of protein dynamics and allosteric regulation: theory, tools and applications
Zhongjie Liang et al.
BRIEFINGS IN BIOINFORMATICS (2020)
The role of ubiquitination in tumorigenesis and targeted drug discovery
Lu Deng et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)
Phase 1 Study of Molibresib (GSK525762), a Bromodomain and Extra-Terminal Domain Protein Inhibitor, in NUT Carcinoma and Other Solid Tumors
Sarina A. Piha-Paul et al.
JNCI CANCER SPECTRUM (2020)
Fast Prediction of Protein Methylation Sites Using a Sequence-Based Feature Selection Technique
Leyi Wei et al.
IEEE-ACM TRANSACTIONS ON COMPUTATIONAL BIOLOGY AND BIOINFORMATICS (2019)
4mCPred: machine learning methods for DNA N4-methylcytosine sites prediction
Wenying He et al.
BIOINFORMATICS (2019)
Computational analysis and prediction of lysine malonylation sites by exploiting informative features in an integrative machine-learning framework
Yanju Zhang et al.
BRIEFINGS IN BIOINFORMATICS (2019)
DNA Methylation and Susceptibility to Autism Spectrum Disorder
Martine W. Tremblay et al.
ANNUAL REVIEW OF MEDICINE, VOL 70 (2019)
A deep learning method to more accurately recall known lysine acetylation sites
Meiqi Wu et al.
BMC BIOINFORMATICS (2019)
PPI-Detect: A Support Vector Machine Model for Sequence-Based Prediction of Protein-Protein Interactions
Sandra Romero-Molina et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2019)
Site-specific ubiquitylation and SUMOylation using genetic-code expansion and sortase
Maximilian Fottner et al.
NATURE CHEMICAL BIOLOGY (2019)
Breaking the chains: deubiquitylating enzyme specificity begets function
Michael J. Clague et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)
A post-translational modification of human Norovirus capsid protein attenuates glycan binding
Alvaro Mallagaray et al.
NATURE COMMUNICATIONS (2019)
Allosteric mechanism of the circadian protein Vivid resolved through Markov state model and machine learning analysis
Hongyu Zhou et al.
PLOS COMPUTATIONAL BIOLOGY (2019)
Future challenges with DNA-encoded chemical libraries in the drug discovery domain
Guixian Zhao et al.
EXPERT OPINION ON DRUG DISCOVERY (2019)
Concepts of Catalysis in Site-Selective Protein Modifications
Patrick G. Isenegger et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2019)
Prediction of Orthosteric and Allosteric Regulations on Cannabinoid Receptors Using Supervised Machine Learning Classifiers
Yuemin Bian et al.
MOLECULAR PHARMACEUTICS (2019)
Applications of machine learning in drug discovery and development
Jessica Vamathevan et al.
NATURE REVIEWS DRUG DISCOVERY (2019)
DeepFunc: A Deep Learning Framework for Accurate Prediction of Protein Functions from Protein Sequences and Interactions
Fuhao Zhang et al.
PROTEOMICS (2019)
Coupling Molecular Dynamics and Deep Learning to Mine Protein Conformational Space
Matteo T. Degiacomi
STRUCTURE (2019)
Gain-of-Function Mutations: An Emerging Advantage for Cancer Biology
Yongsheng Li et al.
TRENDS IN BIOCHEMICAL SCIENCES (2019)
Investigation of the impact of PTMs on the protein backbone conformation
Pierrick Craveur et al.
AMINO ACIDS (2019)
Targeting protein methylation: from chemical tools to precision medicines
David Dilworth et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2019)
Targeted protein degradation: elements of PROTAC design
Stacey-Lynn Paiva et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2019)
Target 2035: probing the human proteome
Adrian J. Carter et al.
DRUG DISCOVERY TODAY (2019)
Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design
Yulan Wang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Discovery of small molecule binders of human FSHR(TMD) with novel structural scaffolds by integrating structural bioinformatics and machine learning algorithms
Bhawana Sahu et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2019)
Bromodomains: a new target class for drug development
Andrea G. Cochran et al.
NATURE REVIEWS DRUG DISCOVERY (2019)
The regulation, functions and clinical relevance of arginine methylation
Ernesto Guccione et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)
The roles of DNA, RNA and histone methylation in ageing and cancer
Ewa M. Michalak et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)
The importance of non-histone protein methylation in cancer therapy
Manuel Rodriguez-Paredes et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)
Drugging K-RasG12C through covalent inhibitors: Mission possible?
Duan Ni et al.
PHARMACOLOGY & THERAPEUTICS (2019)
Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses
Lei Wang et al.
SCIENCE (2019)
Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma
Chul-Hwan Lee et al.
GENES & DEVELOPMENT (2019)
Regulation of histone methylation by automethylation of PRC2
Xueyin Wang et al.
GENES & DEVELOPMENT (2019)
Deep learning enables rapid identification of potent DDR1 kinase inhibitors
Alex Zhavoronkov et al.
NATURE BIOTECHNOLOGY (2019)
Targeting epigenetic machinery: Emerging novel allosteric inhibitors
Fei Ye et al.
PHARMACOLOGY & THERAPEUTICS (2019)
A robotic platform for flow synthesis of organic compounds informed by AI planning
Connor W. Coley et al.
SCIENCE (2019)
Validation of the protein kinase PfCLK3 as a multistage cross-species malarial drug target
Mahmood M. Alam et al.
SCIENCE (2019)
Advancing Drug Discovery via Artificial Intelligence
H. C. Stephen Chan et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2019)
Discovery of SIAIS178 as an Effective BCR-ABL Degrader by Recruiting Von Hippel-Lindau (VHL) E3 Ubiquitin Ligase
Quanju Zhao et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
Jude Canon et al.
NATURE (2019)
Cracking KRAS
Asher Mullard
NATURE REVIEWS DRUG DISCOVERY (2019)
Targeted protein degradation: expanding the toolbox
Matthieu Schapira et al.
NATURE REVIEWS DRUG DISCOVERY (2019)
Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is Implicated in Tumorigenesis
Yi Zeng et al.
CELL REPORTS (2019)
Palmitoylation stabilizes PD-L1 to promote breast tumor growth
Yi Yang et al.
CELL RESEARCH (2019)
Oral semaglutide for the treatment of type 2 diabetes
Maka S. Hedrington et al.
EXPERT OPINION ON PHARMACOTHERAPY (2019)
Enhancing Retrosynthetic Reaction Prediction with Deep Learning Using Multiscale Reaction Classification
Javier L. Baylon et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2019)
A guide to deep learning in healthcare
Andre Esteva et al.
NATURE MEDICINE (2019)
Mapping biologically active chemical space to accelerate drug discovery
G. Sitta Sittampalam et al.
NATURE REVIEWS DRUG DISCOVERY (2019)
UniProt: a worldwide hub of protein knowledge
Alex Bateman et al.
NUCLEIC ACIDS RESEARCH (2019)
dbPTM in 2019: exploring disease association and cross-talk of post-translational modifications
Kai-Yao Huang et al.
NUCLEIC ACIDS RESEARCH (2019)
Organic synthesis in a modular robotic system driven by a chemical programming language
Sebastian Steiner et al.
SCIENCE (2019)
Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase
Blake E. Smith et al.
NATURE COMMUNICATIONS (2019)
The timeline of epigenetic drug discovery: from reality to dreams
A. Ganesan et al.
CLINICAL EPIGENETICS (2019)
How machine learning can assist the interpretation of ab initio molecular dynamics simulations and conceptual understanding of chemistry
Florian Hase et al.
CHEMICAL SCIENCE (2019)
Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML
Matthias Brand et al.
CELL CHEMICAL BIOLOGY (2019)
Epigenetic regulation of the innate immune response to infection
Qian Zhang et al.
NATURE REVIEWS IMMUNOLOGY (2019)
Breaking the law: unconventional strategies for antibody diversification
Alexia Kanyavuz et al.
NATURE REVIEWS IMMUNOLOGY (2019)
PROTACs: great opportunities for academia and industry
Xiuyun Sun et al.
SIGNAL TRANSDUCTION AND TARGETED THERAPY (2019)
Highlighted STAT3 as a potential drug target for cancer therapy
Haeri Lee et al.
BMB REPORTS (2019)
Extraction of protein-protein interactions (PPIs) from the literature by deep convolutional neural networks with various feature embeddings
Sung-Pil Choi
JOURNAL OF INFORMATION SCIENCE (2018)
Protac-Induced Protein Degradation in Drug Discovery: Breaking the Rules or Just Making New Ones?
Ian Churcher
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Enriching biologically relevant chemical space around 2-aminothiazole template for anticancer drug development
Sarah Titus et al.
MEDICINAL CHEMISTRY RESEARCH (2018)
Ubiquitylation at the crossroads of development and disease
Michael Rape
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)
ActiveDriverDB: human disease mutations and genome variation in post-translational modification sites of proteins
Michal Krassowski et al.
NUCLEIC ACIDS RESEARCH (2018)
DrugBank 5.0: a major update to the DrugBank database for 2018
David S. Wishart et al.
NUCLEIC ACIDS RESEARCH (2018)
Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins
Liming Liu
PROTEIN & CELL (2018)
Machine Learning in Computer-Aided Synthesis Planning
Connor W. Coley et al.
ACCOUNTS OF CHEMICAL RESEARCH (2018)
Optimizing Antimicrobial Peptide Dendrimers in Chemical Space
Thissa N. Siriwardena et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)
PROTACs: An Emerging Targeting Technique for Protein Degradation in Drug Discovery
Shanshan Gu et al.
BIOESSAYS (2018)
Exploring drug space with ChemMaps.com
Alexandre Borrel et al.
BIOINFORMATICS (2018)
Quokka: a comprehensive tool for rapid and accurate prediction of kinase family-specific phosphorylation sites in the human proteome
Fuyi Li et al.
BIOINFORMATICS (2018)
A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers
Ashton C. Berger et al.
CANCER CELL (2018)
Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1
Chia-Wei Li et al.
CANCER CELL (2018)
Glycosylation of Recombinant Anticancer Therapeutics in Different Expression Systems with Emerging Technologies
Tariq Nadeem et al.
CANCER RESEARCH (2018)
Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor
Matthew R. Janes et al.
CELL (2018)
ALLO: A tool to discriminate and prioritize allosteric pockets
Rahmad Akbar et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2018)
Synthetic post-translational modification of histones
Simon Nadal et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2018)
The present and the future of motif-mediated protein-protein interactions
Moon-Hyeong Seo et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2018)
The rise of deep learning in drug discovery
Hongming Chen et al.
DRUG DISCOVERY TODAY (2018)
Characterizing disease-associated changes in post-translational modifications by mass spectrometry
Camilla Thygesen et al.
EXPERT REVIEW OF PROTEOMICS (2018)
DNA-encoded chemical libraries - achievements and remaining challenges
Nicholas Favalli et al.
FEBS LETTERS (2018)
Comparative Evaluation of Covalent Docking Tools
Andrea Scarpino et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2018)
Machine learning approaches to evaluate correlation patterns in allosteric signaling: A case study of the PDZ2 domain
Mohsen Botlani et al.
JOURNAL OF CHEMICAL PHYSICS (2018)
Recognition of protein allosteric states and residues: Machine learning approaches
Hongyu Zhou et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2018)
Crystal Structure of Human Dual-Specificity Tyrosine-Regulated Kinase 3 Reveals New Structural Features and Insights into its Auto-phosphorylation
Kuglae Kim et al.
JOURNAL OF MOLECULAR BIOLOGY (2018)
Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation
Qicong Shen et al.
NATURE (2018)
Design of glycosylation sites by rapid synthesis and analysis of glycosyltransferases
Weston Kightlinger et al.
NATURE CHEMICAL BIOLOGY (2018)
Unexplored therapeutic opportunities in the human genome
Tudor I. Oprea et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
Cryo-EM in drug discovery: achievements, limitations and prospects
Jean-Paul Renaud et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
Kinase inhibitors: the road ahead
Fleur M. Ferguson et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
Principles for targeting RNA with drug-like small molecules
Katherine Deigan Warner et al.
NATURE REVIEWS DRUG DISCOVERY (2018)
Integrative omics for health and disease
Konrad J. Karczewski et al.
NATURE REVIEWS GENETICS (2018)
Improving succinylation prediction accuracy by incorporating the secondary structure via helix, strand and coil, and evolutionary information from profile bigrams
Abdollah Dehzangi et al.
PLOS ONE (2018)
New molecular switch architectures
Jared D. Harris et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Protein dynamics in the solid-state from 2H NMR lineshape analysis. III. MOMD in the presence of Magic Angle Spinning
Eva Meirovitch et al.
SOLID STATE NUCLEAR MAGNETIC RESONANCE (2018)
Machine intelligence decrypts -lapachone as an allosteric 5-lipoxygenase inhibitor
Tiago Rodrigues et al.
CHEMICAL SCIENCE (2018)
Posttranslational Modifications of RAS Proteins
Ian Ahearn et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2018)
Computational Chemical Synthesis Analysis and Pathway Design
Fan Feng et al.
FRONTIERS IN CHEMISTRY (2018)
Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs
Katrina Meyer et al.
CELL (2018)
Protein palmitoylation and cancer
Pin-Joe Ko et al.
EMBO REPORTS (2018)
Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1
Joseph Schoepfer et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Controlling an organic synthesis robot with machine learning to search for new reactivity
Jaroslaw M. Granda et al.
NATURE (2018)
The protein histidine phosphatase LHPP is a tumour suppressor
Sravanth K. Hindupur et al.
NATURE (2018)
Machine learning for molecular and materials science
Keith T. Butler et al.
NATURE (2018)
Machine learning at the energy and intensity frontiers of particle physics
Alexander Radovic et al.
NATURE (2018)
Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability
Nahid Iglesias et al.
NATURE (2018)
Planning chemical syntheses with deep neural networks and symbolic AI
Marwin H. S. Segler et al.
NATURE (2018)
Post-translational site-selective protein backbone alpha-deuteration
Sebastien R. G. Galan et al.
NATURE CHEMICAL BIOLOGY (2018)
SUMOgo: Prediction of sumoylation sites on lysines by motif screening models and the effects of various post-translational modifications
Chi-Chang Chang et al.
SCIENTIFIC REPORTS (2018)
The Future of Bioorthogonal Chemistry
Neal K. Devaraj
ACS CENTRAL SCIENCE (2018)
PTMD: A Database of Human Disease-associated Post-translational Modifications
Haodong Xu et al.
GENOMICS PROTEOMICS & BIOINFORMATICS (2018)
Hot spot prediction in protein-protein interactions by an ensemble system
Quanya Liu et al.
BMC SYSTEMS BIOLOGY (2018)
N6-methyladenine DNA Modification in Glioblastoma
Qi Xie et al.
CELL (2018)
Genetic Incorporation of Olefin Cross-Metathesis Reaction Tags for Protein Modification
Bhaskar Bhushan et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)
SumSec: Accurate Prediction of Sumoylation Sites Using Predicted Secondary Structure
Abdollah Dehzangi et al.
MOLECULES (2018)
Protein Dynamics in Solution by Quantitative Crosslinking/Mass Spectrometry
Zhuo A. Chen et al.
TRENDS IN BIOCHEMICAL SCIENCES (2018)
Increasing G9a automethylation sensitizes B acute lymphoblastic leukemia cells to glucocorticoid-induced death
Coralie Poulard et al.
CELL DEATH & DISEASE (2018)
Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer
Jeffrey A. Schneider et al.
NATURE COMMUNICATIONS (2018)
Using Machine Learning To Predict Suitable Conditions for Organic Reactions
Hanyu Gao et al.
ACS CENTRAL SCIENCE (2018)
Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space
Sara E. Kearney et al.
ACS CENTRAL SCIENCE (2018)
Integration of A Deep Learning Classifier with A Random Forest Approach for Predicting Malonylation Sites
Zhen Chen et al.
GENOMICS PROTEOMICS & BIOINFORMATICS (2018)
Mutant and Wild-Type Tumor Suppressor p53 Induces p300 Autoacetylation
Stephanie Kaypee et al.
ISCIENCE (2018)
Unmasking Fucosylation: from Cell Adhesion to Immune System Regulation and Diseases
Jun Li et al.
CELL CHEMICAL BIOLOGY (2018)
Post-Translational Modifications of Protein Backbones: Unique Functions, Mechanisms, and Challenges
Manuel M. Mueller
BIOCHEMISTRY (2018)
Cryo-EM for Small Molecules Discovery, Design, Understanding, and Application
Giovanna Scapin et al.
CELL CHEMICAL BIOLOGY (2018)
Deep learning for chemical reaction prediction
David Fooshee et al.
MOLECULAR SYSTEMS DESIGN & ENGINEERING (2018)
cBinderDB: a covalent binding agent database
Jiewen Du et al.
BIOINFORMATICS (2017)
Evolutionary conservation of Ebola virus proteins predicts important functions at residue level
Ahmed Arslan et al.
BIOINFORMATICS (2017)
DNA-encoded chemistry: enabling the deeper sampling of chemical space
Robert A. Goodnow et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
A comprehensive map of molecular drug targets
Rita Santos et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Covalent inhibitors design and discovery
Stephane De Cesco et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy
Fatima Ardito et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)
Statistical Analysis and Prediction of Covalent Ligand Targeted Cysteine Residues
Weilin Zhang et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2017)
Computational Multitarget Drug Design
Weilin Zhang et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2017)
Indazole-Based Covalent Inhibitors To Target Drug-Resistant Epidermal Growth Factor Receptor
Stefano Tomassi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Determining Cysteines Available for Covalent Inhibition Across the Human Kinome
Zheng Zhao et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases
Philip A. Harris et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Advancing the prediction accuracy of protein-protein interactions by utilizing evolutionary information from position-specific scoring matrix and ensemble classifier
Lei Wang et al.
JOURNAL OF THEORETICAL BIOLOGY (2017)
Dermatologist-level classification of skin cancer with deep neural networks
Andre Esteva et al.
NATURE (2017)
Structural insight into allosteric modulation of protease-activated receptor 2
Robert K. Y. Cheng et al.
NATURE (2017)
The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1
Andrew A. Wylie et al.
NATURE (2017)
Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria
Xiaozhou Luo et al.
NATURE CHEMICAL BIOLOGY (2017)
Site-specific incorporation of phosphotyrosine using an expanded genetic code
Christian Hoppmann et al.
NATURE CHEMICAL BIOLOGY (2017)
Inhibition of USP10 induces degradation of oncogenic FLT3
Ellen L. Weisberg et al.
NATURE CHEMICAL BIOLOGY (2017)
Structural basis of PROTAC cooperative recognition for selective protein degradation
Morgan S. Gadd et al.
NATURE CHEMICAL BIOLOGY (2017)
Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation
Pingzhao Zhang et al.
NATURE MEDICINE (2017)
Post-translational mutagenesis for installation of natural and unnatural amino acid side chains into recombinant proteins
Tom H. Wright et al.
NATURE PROTOCOLS (2017)
Protein O-GlcNAcylation: emerging mechanisms and functions
Xiaoyong Yang et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)
Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease
Robert J. Andrew et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Cognitive 'Omics': Pattern-Bases Validation of Potential Drug Targets
Istvan Gyertyan
TRENDS IN PHARMACOLOGICAL SCIENCES (2017)
Chemical space guided discovery of antimicrobial bridged bicyclic peptides against Pseudomonas aeruginosa and its biofilms
Ivan Di Bonaventura et al.
CHEMICAL SCIENCE (2017)
Predicting allosteric mutants that increase activity of a major antibiotic resistance enzyme
M. J. Latallo et al.
CHEMICAL SCIENCE (2017)
Machine Learning and Network Analysis of Molecular Dynamics Trajectories Reveal Two Chains of Red/Ox-specific Residue Interactions in Human Protein Disulfide Isomerase
Razieh Karamzadeh et al.
SCIENTIFIC REPORTS (2017)
Myristoylation: An Important Protein Modification in the Immune Response
Daniel Ikenna Udenwobele et al.
FRONTIERS IN IMMUNOLOGY (2017)
Retrosynthetic Reaction Prediction Using Neural Sequence-to-Sequence Models
Bowen Liu et al.
ACS CENTRAL SCIENCE (2017)
The Proteasome in Modern Drug Discovery: Second Life of a Highly Valuable Drug Target
Philipp M. Cromm et al.
ACS CENTRAL SCIENCE (2017)
A Mini-Review on Thalidomide: Chemistry, Mechanisms of Action, Therapeutic Potential and Anti-Angiogenic Properties in Multiple Myeloma
Annalisa Mercurio et al.
CURRENT MEDICINAL CHEMISTRY (2017)
Targeting the ubiquitin-proteasome system for cancer treatment: discovering novel inhibitors from nature and drug repurposing
Claire L. Soave et al.
CANCER AND METASTASIS REVIEWS (2017)
Proteome-wide Map of Targets of T790M-EGFR-Directed Covalent Inhibitors
Sherry Niessen et al.
CELL CHEMICAL BIOLOGY (2017)
Modeling covalent-modifier drugs
Ernest Awoonor-Williams et al.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2017)
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Philipp M. Cromm et al.
CELL CHEMICAL BIOLOGY (2017)
A post-translational modification switch controls coactivator function of histone methyltransferases G9a and GLP
Coralie Poulard et al.
EMBO REPORTS (2017)
Privileged Electrophile Sensors: A Resource for Covalent Drug Development
Marcus John Curtis Long et al.
CELL CHEMICAL BIOLOGY (2017)
Drugging the 'undruggable' cancer targets
Chi V. Dang et al.
NATURE REVIEWS CANCER (2017)
Sequence-based prediction of protein protein interaction using a deep-learning algorithm
Tanlin Sun et al.
BMC BIOINFORMATICS (2017)
Recognition of substrate degrons by E3 ubiquitin ligases and modulation by small-molecule mimicry strategies
Xavier Lucas et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2017)
Neural-Symbolic Machine Learning for Retrosynthesis and Reaction Prediction
Marwin H. S. Segler et al.
CHEMISTRY-A EUROPEAN JOURNAL (2017)
Designed covalent allosteric modulators: an emerging paradigm in drug discovery
Shaoyong Lu et al.
DRUG DISCOVERY TODAY (2017)
Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL
Ashton C. Lai et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Results of the Phase I Trial of RG7112, a Small-Molecule MDM2 Antagonist in Leukemia
Michael Andreeff et al.
CLINICAL CANCER RESEARCH (2016)
Site-selective protein-modification chemistry for basic biology and drug development
Nikolaus Krall et al.
NATURE CHEMISTRY (2016)
From Chemical Mutagenesis to Post-Expression Mutagenesis: A 50 Year Odyssey
Tom H. Wright et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Targeted Covalent Inhibitors for Drug Design
Thomas A. Baillie
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Cysteinome: The first comprehensive database for proteins with targetable cysteine and their covalent inhibitors
Sijin Wu et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)
Post-translational regulation of the β-secretase BACE1
Wataru Araki
BRAIN RESEARCH BULLETIN (2016)
Drugging the undruggables: exploring the ubiquitin system for drug development
Xiaodong Huang et al.
CELL RESEARCH (2016)
Covalent targeting of acquired cysteines in cancer
Marieke Visscher et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2016)
Computational approaches to investigating allostery
Ora Schueler-Furman et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2016)
Protein-protein interaction inhibitors: advances in anticancer drug design
Leonardo G. Ferreira et al.
EXPERT OPINION ON DRUG DISCOVERY (2016)
The Significance of Ras Activity in Pancreatic Cancer Initiation
Craig D. Logsdon et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2016)
Chemical Space of DNA-Encoded Libraries
Raphael M. Franzini et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors
Philip A. Harris et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Identification of a Benzoisoxazoloazepine Inhibitor (CPI-0610) of the Bromodomain and Extra-Terminal (BET) Family as a Candidate for Human Clinical Trials
Brian K. Albrecht et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
K-Ras protein as a drug target
Frank McCormick
JOURNAL OF MOLECULAR MEDICINE-JMM (2016)
pSuc-Lys: Predict lysine succinylation sites in proteins with PseAAC and ensemble random forest approach
Jianhua Jia et al.
JOURNAL OF THEORETICAL BIOLOGY (2016)
A Random Forest Model for Predicting Allosteric and Functional Sites on Proteins
Ava S-Y. Chen et al.
MOLECULAR INFORMATICS (2016)
Proteome-wide covalent ligand discovery in native biological systems
Keriann M. Backus et al.
NATURE (2016)
HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma
Omid Tavana et al.
NATURE MEDICINE (2016)
Characterization of proteins by in-cell NMR spectroscopy in cultured mammalian cells
Letizia Barbieri et al.
NATURE PROTOCOLS (2016)
Protein prenylation: unique fats make their mark on biology
Mei Wang et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)
Palmitoylation in Alzheimer's disease and other neurodegenerative diseases
Eunsil Cho et al.
PHARMACOLOGICAL RESEARCH (2016)
Posttranslational mutagenesis: A chemical strategy for exploring protein side-chain diversity
Tom H. Wright et al.
SCIENCE (2016)
Screening for covalent inhibitors using DNA-display of small molecule libraries functionalized with cysteine reactive moieties
C. Zambaldo et al.
MEDCHEMCOMM (2016)
SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status
Ha Yong Song et al.
ONCOTARGET (2016)
Prediction and validation of protein-protein interactors from genome-wide DNA-binding data using a knowledge-based machine-learning approach
Ashley J. Waardenberg et al.
OPEN BIOLOGY (2016)
Allostery: An Overview of Its History, Concepts, Methods, and Applications
Jin Liu et al.
PLOS COMPUTATIONAL BIOLOGY (2016)
Genome-wide epigenomic profiling for biomarker discovery
Rene A. M. Dirks et al.
CLINICAL EPIGENETICS (2016)
Chemical Methods for Encoding and Decoding of Posttranslational Modifications
Kelly N. Chuh et al.
CELL CHEMICAL BIOLOGY (2016)
The Design of Covalent Allosteric Drugs
Ruth Nussinov et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 55 (2015)
Identifying an essential role of nuclear LC3 for autophagy
Rui Huang et al.
AUTOPHAGY (2015)
AlloPred: prediction of allosteric pockets on proteins using normal mode perturbation analysis
Joe G. Greener et al.
BMC BIOINFORMATICS (2015)
Integrated proteo-genomic approach for early diagnosis and prognosis of cancer
Hem D. Shukla et al.
CANCER LETTERS (2015)
Covalent inhibitors in drug discovery: from accidental discoveries to avoided liabilities and designed therapies
Renato A. Bauer
DRUG DISCOVERY TODAY (2015)
Expanding the ubiquitin code through post-translational modification
Lina Herhaus et al.
EMBO REPORTS (2015)
Regulation and function of the human HSP90AA1 gene
Abbey D. Zuehlke et al.
GENE (2015)
Novel Allosteric Modulators of G Protein-coupled Receptors
Patrick R. Gentry et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Comprehensive Cross-Linking Mass Spectrometry Reveals Parallel Orientation and Flexible Conformations of Plant HOP2-MND1
Evelyn Rampler et al.
JOURNAL OF PROTEOME RESEARCH (2015)
Phogly-PseAAC: Prediction of lysine phosphoglycerylation in proteins incorporating with position-specific propensity
Yan Xu et al.
JOURNAL OF THEORETICAL BIOLOGY (2015)
Safety and efficacy of imatinib in CML over a period of 10 years: data from the randomized CML-study IV
L. Kalmanti et al.
LEUKEMIA (2015)
Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation
Rui Huang et al.
MOLECULAR CELL (2015)
Phosphorylation of LC3 by the Hippo Kinases STK3/STK4 Is Essential for Autophagy
Deepti S. Wilkinson et al.
MOLECULAR CELL (2015)
Small Molecule Targeting of Protein-Protein Interactions through Allosteric Modulation of Dynamics
Benjamin P. Cossins et al.
MOLECULES (2015)
Robots that can adapt like animals
Antoine Cully et al.
NATURE (2015)
DRUG-TARGET INTERACTIONS Stay tuned
Robert A. Copeland
NATURE CHEMICAL BIOLOGY (2015)
SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice
James Palacino et al.
NATURE CHEMICAL BIOLOGY (2015)
HDAC inhibitors still need a home run, despite recent approval
Malini Guha
NATURE REVIEWS DRUG DISCOVERY (2015)
SCFTIR1/AFB-Based Auxin Perception: Mechanism and Role in Plant Growth and Development
Mohammad Salehin et al.
PLANT CELL (2015)
Machine learning: Trends, perspectives, and prospects
M. I. Jordan et al.
SCIENCE (2015)
Effects of N-glycosylation on protein conformation and dynamics: Protein Data Bank analysis and molecular dynamics simulation study
Hui Sun Lee et al.
SCIENTIFIC REPORTS (2015)
The Roles of Post-translational Modifications in the Context of Protein Interaction Networks
Guangyou Duan et al.
PLOS COMPUTATIONAL BIOLOGY (2015)
Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis
Tobias Wauer et al.
EMBO JOURNAL (2015)
iUbiq-Lys: prediction of lysine ubiquitination sites in proteins by extracting sequence evolution information via a gray system model
Wang-Ren Qiu et al.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2015)
Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch
Alaji Bah et al.
NATURE (2015)
PhosphoSitePlus, 2014: mutations, PTMs and recalibrations
Peter V. Hornbeck et al.
NUCLEIC ACIDS RESEARCH (2015)
Phosphorylation of Mutationally Introduced Tyrosine in the Activation Loop of HER2 Confers Gain-of-Function Activity
Zexi Hu et al.
PLOS ONE (2015)
Survey of phosphorylation near drug binding sites in the Protein Data Bank (PDB) and their effects
Kyle P. Smith et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2015)
Intrinsically Disordered Proteins and Intrinsically Disordered Protein Regions
Christopher J. Oldfield et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 83 (2014)
Drugs for Allosteric Sites on Receptors
Cody J. Wenthur et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 54 (2014)
STAT3 Regulation by S-Nitrosylation: Implication for Inflammatory Disease
Jinsu Kim et al.
ANTIOXIDANTS & REDOX SIGNALING (2014)
The impact of R213 mutation on p53-mediated p21 activity
Yan Zhang et al.
BIOCHIMIE (2014)
Drug discovery considerations in the development of covalent inhibitors
Robert Mah et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
Phosphorylation at Ser-181 of Oncogenic KRAS Is Required for Tumor Growth
Carles Barcelo et al.
CANCER RESEARCH (2014)
Multiple evidence strands suggest that there may be as few as 19 000 human protein-coding genes
Iakes Ezkurdia et al.
HUMAN MOLECULAR GENETICS (2014)
Privileged Structures: Efficient Chemical Navigators toward Unexplored Biologically Relevant Chemical Spaces
Jonghoon Kim et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)
Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer
Irfan A. Asangani et al.
NATURE (2014)
A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors
Bryan R. Lannine et al.
NATURE CHEMICAL BIOLOGY (2014)
Ubiquitination in disease pathogenesis and treatment
Doris Popovic et al.
NATURE MEDICINE (2014)
Drugging the undruggable RAS: Mission Possible?
Adrienne D. Cox et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA
Z. Zou et al.
ONCOGENE (2014)
Covalent EGFR inhibitor analysis reveals importance of reversible interactions to potency and mechanisms of drug resistance
Phillip A. Schwartz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
The structural and functional signatures of proteins that undergo multiple events of post-translational modification
Vikas Pejaver et al.
PROTEIN SCIENCE (2014)
In-cell NMR reveals potential precursor of toxic species from SOD1 fALS mutants
Enrico Luchinat et al.
NATURE COMMUNICATIONS (2014)
Global profiling of co- and post-translationally N-myristoylated proteomes in human cells
Emmanuelle Thinon et al.
NATURE COMMUNICATIONS (2014)
Visualization of chemical space for medicinal chemists
Peter Ertl
Journal of Cheminformatics (2014)
Truncated and modified amyloid-beta species
Markus P. Kummer et al.
ALZHEIMERS RESEARCH & THERAPY (2014)
Protein redox chemistry: post-translational cysteine modifications that regulate signal transduction and drug pharmacology
Revati Wani et al.
FRONTIERS IN PHARMACOLOGY (2014)
Cyclin-dependent kinase 5 modulates STAT3 and androgen receptor activation through phosphorylation of Ser727 on STAT3 in prostate cancer cells
Fu-Ning Hsu et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2013)
The COOH-terminus of TM4SF5 in hepatoma cell lines regulates c-Src to form invasive protrusions via EGFR Tyr845 phosphorylation
Oisun Jung et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)
Tumor STAT3 tyrosine phosphorylation status, as a predictor of benefit from adjuvant chemotherapy for breast cancer
Amir Sonnenblick et al.
BREAST CANCER RESEARCH AND TREATMENT (2013)
The Role of Cdk5 in Neuroendocrine Thyroid Cancer
Karine Pozo et al.
CANCER CELL (2013)
Phosphorylation of EZH2 Activates STAT3 Signaling via STAT3 Methylation and Promotes Tumorigenicity of Glioblastoma Stem-like Cells
Eunhee Kim et al.
CANCER CELL (2013)
MDM2 Small-Molecule Antagonist RG7112 Activates p53 Signaling and Regresses Human Tumors in Preclinical Cancer Models
Christian Tovar et al.
CANCER RESEARCH (2013)
Mineralocorticoid Receptor Phosphorylation Regulates Ligand Binding and Renal Response to Volume Depletion and Hyperkalemia
Shigeru Shibata et al.
CELL METABOLISM (2013)
Tuning probe selectivity for chemical proteomics applications
Ute Haedke et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2013)
Expanding medicinal chemistry space
Andy Barker et al.
DRUG DISCOVERY TODAY (2013)
p42/p44 MAPK-mediated Stat3Ser727 phosphorylation is required for progestin-induced full activation of Stat3 and breast cancer growth
Mercedes Tkach et al.
ENDOCRINE-RELATED CANCER (2013)
Deciphering post-translational modification codes
Adam P. Lothrop et al.
FEBS LETTERS (2013)
Perifosine, an AKT inhibitor, modulates ovarian cancer cell line sensitivity to cisplatin-induced growth arrest
Entidhar Al Sawah et al.
GYNECOLOGIC ONCOLOGY (2013)
Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model
Ming-Szu Hung et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2013)
Structure-Activity Studies of Phosphopeptidomimetic Prodrugs Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 3 (Stat3)
Pijus K. Mandal et al.
INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS (2013)
Gadd45a Suppresses Tumor Angiogenesis via Inhibition of the mTOR/STAT3 Protein Pathway
Fang Yang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Differences in the Regulation of K-Ras and H-Ras Isoforms by Monoubiquitination
Rachael Baker et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Exploring the Biologically Relevant Chemical Space for Drug Discovery
Zhi-Luo Deng et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2013)
Acylglycerol kinase augments JAK2/STAT3 signaling in esophageal squamous cells
Xiuting Chen et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
CovalentDock: Automated covalent docking with parameterized covalent linkage energy estimation and molecular geometry constraints
Xuchang Ouyang et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2013)
Docking-Based Virtual Screening of Covalently Binding Ligands: An Orthogonal Lead Discovery Approach
Joerg Schroeder et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts
Raja Bhattacharyya et al.
JOURNAL OF NEUROSCIENCE (2013)
SGT1 regulates Akt signaling by promoting beta-TrCP-dependent PHLPP1 degradation in gastric cancer cells
Ganglong Gao et al.
MOLECULAR BIOLOGY REPORTS (2013)
Lyn, a Src family kinase, regulates activation of epidermal growth factor receptors in lung adenocarcinoma cells
Parnetta Sutton et al.
MOLECULAR CANCER (2013)
K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
Jonathan M. Ostrem et al.
NATURE (2013)
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain
Lindsey I. James et al.
NATURE CHEMICAL BIOLOGY (2013)
Atomic-resolution monitoring of protein maturation in live human cells by NMR
Lucia Banci et al.
NATURE CHEMICAL BIOLOGY (2013)
Deferoxamine inhibits iron induced hippocampal tau phosphorylation in the Alzheimer transgenic mouse brain
Chuang Guo et al.
NEUROCHEMISTRY INTERNATIONAL (2013)
AKT Activation and Telomerase Reverse Transcriptase Expression Are Concurrently Associated with Prognosis of Gastric Cancer
Takamitsu Sasaki et al.
PATHOBIOLOGY (2013)
Initial Testing of the MDM2 Inhibitor RG7112 by the Pediatric Preclinical Testing Program
Hernan Carol et al.
PEDIATRIC BLOOD & CANCER (2013)
Aberrant Glycogen Synthase Kinase 3β Is Involved in Pancreatic Cancer Cell Invasion and Resistance to Therapy
Ayako Kitano et al.
PLOS ONE (2013)
CSTP1, a Novel Protein Phosphatase, Blocks Cell Cycle, Promotes Cell Apoptosis, and Suppresses Tumor Growth of Bladder Cancer by Directly Dephosphorylating Akt at Ser473 Site
De-Xiang Zhuo et al.
PLOS ONE (2013)
PKG II Inhibits EGF/EGFR-Induced Migration of Gastric Cancer Cells
Lu Jiang et al.
PLOS ONE (2013)
Durable tumor regression in genetically altered malignant rhabdoid tumors by inhibition of methyltransferase EZH2
Sarah K. Knutson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Accurate prediction of hot spot residues through physicochemical characteristics of amino acid sequences
Peng Chen et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2013)
Lysine Methylation Promotes VEGFR-2 Activation and Angiogenesis
Edward J. Hartsough et al.
SCIENCE SIGNALING (2013)
Podocalyxin regulates astrocytoma cell invasion and survival against temozolomide
Hao Wu et al.
EXPERIMENTAL AND THERAPEUTIC MEDICINE (2013)
Discovery of RG7112: A Small-Molecule MDM2 Inhibitor in Clinical Development
Binh Vu et al.
ACS MEDICINAL CHEMISTRY LETTERS (2013)
Post-translational modification and conformational state of Heat Shock Protein 90 differentially affect binding of chemically diverse small molecule inhibitors
Kristin Beebe et al.
ONCOTARGET (2013)
Ratio of Aβ42/P-tau181p in CSF is associated with aberrant default mode network in AD
Xiaozhen Li et al.
SCIENTIFIC REPORTS (2013)
Role of STAT3 in Cancer Metastasis and Translational Advances
Mohammad Zahid Kamran et al.
BIOMED RESEARCH INTERNATIONAL (2013)
Acid ceramidase induces sphingosine kinase 1/S1P receptor 2-mediated activation of oncogenic Akt signaling
T. H. Beckham et al.
ONCOGENESIS (2013)
Exploring Chemical Space for Drug Discovery Using the Chemical Universe Database
Jean-Louis Reymond et al.
ACS CHEMICAL NEUROSCIENCE (2012)
Dual modification of Alzheimer's disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach
Stefani N. Thomas et al.
ACTA NEUROPATHOLOGICA (2012)
Ack1 Tyrosine Kinase Activation Correlates with Pancreatic Cancer Progression
Kiran Mahajan et al.
AMERICAN JOURNAL OF PATHOLOGY (2012)
Prediction of lysine ubiquitination with mRMR feature selection and analysis
Yudong Cai et al.
AMINO ACIDS (2012)
Reversible Covalent Inhibition of a Protein Target
Chang-Uk Lee et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2012)
Withaferin A inhibits JAK/STAT3 signaling and induces apoptosis of human renal carcinoma Caki cells
Hee Jung Urn et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)
Post-translational modifications induce significant yet not extreme changes to protein structure
Fuxiao Xin et al.
BIOINFORMATICS (2012)
Auto-acetylation stabilizes p300 in cardiac myocytes during acute oxidative stress, promoting STAT3 accumulation and cell survival
Sumit Jain et al.
BREAST CANCER RESEARCH AND TREATMENT (2012)
Pyrvinium pamoate inhibits proliferation of myeloma/erythroleukemia cells by suppressing mitochondrial respiratory complex I and STAT3
Yasuo Harada et al.
CANCER LETTERS (2012)
Anacardic acid (6-pentadecylsalicylic acid) induces apoptosis of prostate cancer cells through inhibition of androgen receptor and activation of p53 signaling
Jing Tan et al.
CHINESE JOURNAL OF CANCER RESEARCH (2012)
Tissue microarray-based study of patients with lymph node-positive breast cancer shows tyrosine phosphorylation of signal transducer and activator of transcription 3 (tyrosine705-STAT3) is a marker of good prognosis
Amir Sonnenblick et al.
CLINICAL & TRANSLATIONAL ONCOLOGY (2012)
Drug discovery for a new generation of covalent drugs
Amit S. Kalgutkar et al.
EXPERT OPINION ON DRUG DISCOVERY (2012)
Hedyotis diffusa Willd Inhibits Colorectal Cancer Growth in Vivo via Inhibition of STAT3 Signaling Pathway
Qiaoyan Cai et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)
Analysis and Functional Prediction of Reactive Cysteine Residues
Stefano M. Marino et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Heat Shock Protein 90α (Hsp90α) Is Phosphorylated in Response to DNA Damage and Accumulates in Repair Foci
Maria Quanz et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Phosphorylated EGFR expression may predict outcome of EGFR-TKIs therapy for the advanced NSCLC patients with wild-type EGFR
Fen Wang et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2012)
Role and Regulation of STAT3 Phosphorylation at Ser727 in Melanocytes and Melanoma Cells
Masanobu Sakaguchi et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2012)
Irreversible Inhibition of Epidermal Growth Factor Receptor Activity by 3-Aminopropanamides
Caterina Carmi et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Irreversible Protein Kinase Inhibitors: Balancing the Benefits and Risks
Tjeerd Barf et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
EGFR S1166 Phosphorylation Induced by a Combination of EGF and Gefitinib Has a Potentially Negative Impact on Lung Cancer Cell Growth
Bobby Fachrizal Assiddiq et al.
JOURNAL OF PROTEOME RESEARCH (2012)
Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles
Iana M. Serafimova et al.
NATURE CHEMICAL BIOLOGY (2012)
Epigenetic protein families: a new frontier for drug discovery
Cheryl H. Arrowsmith et al.
NATURE REVIEWS DRUG DISCOVERY (2012)
Histone methylation: a dynamic mark in health, disease and inheritance
Eric L. Greer et al.
NATURE REVIEWS GENETICS (2012)
Regulating the regulator: post-translational modification of RAS
Ian M. Ahearn et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53
Gaofeng Cui et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression
F. Pareja et al.
ONCOGENE (2012)
SUMOhydro: A Novel Method for the Prediction of Sumoylation Sites Based on Hydrophobic Properties
Yong-Zi Chen et al.
PLOS ONE (2012)
Structurally Modified Curcumin Analogs Inhibit STAT3 Phosphorylation and Promote Apoptosis of Human Renal Cell Carcinoma and Melanoma Cell Lines
Matthew A. Bill et al.
PLOS ONE (2012)
Luteolin Induces Carcinoma Cell Apoptosis through Binding Hsp90 to Suppress Constitutive Activation of STAT3
Jin Fu et al.
PLOS ONE (2012)
Vapor of Volatile Oils from Litsea cubeba Seed Induces Apoptosis and Causes Cell Cycle Arrest in Lung Cancer Cells
Soma Seal et al.
PLOS ONE (2012)
Regulation of RAS oncogenicity by acetylation
Moon Hee Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Dephosphorylation of cardiac proteins in vitro - a matter of phosphatase specificity
Cathrine Husberg et al.
PROTEOMICS (2012)
EGFR Tyrosine 845 Phosphorylation-Dependent Proliferation and Transformation of Breast Cancer Cells Require Activation of p38 MAPK
Kelly L. Mueller et al.
TRANSLATIONAL ONCOLOGY (2012)
Allosteric post-translational modification codes
Ruth Nussinov et al.
TRENDS IN BIOCHEMICAL SCIENCES (2012)
RB1 Methylation by SMYD2 Enhances Cell Cycle Progression through an Increase of RB1 Phosphorylation
Hyun-Soo Cho et al.
NEOPLASIA (2012)
XZH-5 inhibits STAT3 phosphorylation and causes apoptosis in human hepatocellular carcinoma cells
Yan Liu et al.
APOPTOSIS (2011)
Learning probabilistic models of hydrogen bond stability from molecular dynamics simulation trajectories
Igor Chikalov et al.
BMC BIOINFORMATICS (2011)
BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
Jake E. Delmore et al.
CELL (2011)
Cross-talk between Phospho-STAT3 and PLCγ1 Plays a Critical Role in Colorectal Tumorigenesis
Peng Zhang et al.
MOLECULAR CANCER RESEARCH (2011)
Incorporating Distant Sequence Features and Radial Basis Function Networks to Identify Ubiquitin Conjugation Sites
Tzong-Yi Lee et al.
PLOS ONE (2011)
GPS 2.1: enhanced prediction of kinase-specific phosphorylation sites with an algorithm of motif length selection
Yu Xue et al.
PROTEIN ENGINEERING DESIGN & SELECTION (2011)
Ubiquitination of K-Ras Enhances Activation and Facilitates Binding to Select Downstream Effectors
Atsuo T. Sasaki et al.
SCIENCE SIGNALING (2011)
Proteome-wide post-translational modification statistics: frequency analysis and curation of the swiss-prot database
George A. Khoury et al.
SCIENTIFIC REPORTS (2011)
Targeting protein prenylation for cancer therapy
Norbert Berndt et al.
NATURE REVIEWS CANCER (2011)
Bioactivity-Guided Navigation of Chemical Space
Robin S. Bon et al.
ACCOUNTS OF CHEMICAL RESEARCH (2010)
Glycosylation of Therapeutic Proteins An Effective Strategy to Optimize Efficacy
Ricardo J. Sola et al.
BIODRUGS (2010)
Design of Potent IGF1-R Inhibitors Related to Bis-azaindoles
Conception Nemecek et al.
CHEMICAL BIOLOGY & DRUG DESIGN (2010)
Genetically Directing ε-N, N-Dimethyl-L-Lysine in Recombinant Histones
Duy P. Nguyen et al.
CHEMISTRY & BIOLOGY (2010)
Allostery and population shift in drug discovery
Gozde Kar et al.
CURRENT OPINION IN PHARMACOLOGY (2010)
Ligand efficiency indices for an effective mapping of chemico-biological space: the concept of an atlas-like representation
Cele Abad-Zapatero et al.
DRUG DISCOVERY TODAY (2010)
Druggable pockets and binding site centric chemical space: a paradigm shift in drug discovery
Stephanie Perot et al.
DRUG DISCOVERY TODAY (2010)
Epigenetic therapy: targeting histones and their modifications in human disease
Akash Gunjan et al.
FUTURE MEDICINAL CHEMISTRY (2010)
Regulation of the autophagy protein LC3 by phosphorylation
Salvatore J. Cherra et al.
JOURNAL OF CELL BIOLOGY (2010)
Quantitative reactivity profiling predicts functional cysteines in proteomes
Eranthie Weerapana et al.
NATURE (2010)
Epigenetic modifications and human disease
Anna Portela et al.
NATURE BIOTECHNOLOGY (2010)
Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1
Etienne Boulter et al.
NATURE CELL BIOLOGY (2010)
Chemical phylogenetics of histone deacetylases
James E. Bradner et al.
NATURE CHEMICAL BIOLOGY (2010)
Phosphorylation of Ser312 contributes to tumor suppression by p53 in vivo
Elizabeth A. Slee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Identification, analysis, and prediction of protein ubiquitination sites
Predrag Radivojac et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2010)
Glycosylation Protects Proteins against Free Radicals Generated from Toxic Xenobiotics
Vaclav Martinek et al.
TOXICOLOGICAL SCIENCES (2010)
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
Ellen M. Sletten et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)
Prediction of hot spot residues at protein-protein interfaces by combining machine learning and energy-based methods
Stefano Lise et al.
BMC BIOINFORMATICS (2009)
Chemical Modification of Proteins at Cysteine: Opportunities in Chemistry and Biology
Justin M. Chalker et al.
CHEMISTRY-AN ASIAN JOURNAL (2009)
Protein-Protein Interaction Inhibition (2P2I): Fewer and Fewer Undruggable Targets
Stephane Betzi et al.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2009)
Hsp90 is regulated by a switch point in the C-terminal domain
Marco Retzlaff et al.
EMBO REPORTS (2009)
Alzheimer Disease Aβ Production in the Absence of S-Palmitoylation-dependent Targeting of BACE1 to Lipid Rafts
Kulandaivelu S. Vetrivel et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
AutoDock4 and AutoDockTools4: Automated Docking with Selective Receptor Flexibility
Garrett M. Morris et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2009)
Brd4 Coactivates Transcriptional Activation of NF-κB via Specific Binding to Acetylated RelA
Bo Huang et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Ras acylation, compartmentalization and signaling nanoclusters (Review)
Yoav I. Henis et al.
MOLECULAR MEMBRANE BIOLOGY (2009)
Bioactivity-guided mapping and navigation of chemical space
Steffen Renner et al.
NATURE CHEMICAL BIOLOGY (2009)
Interactive exploration of chemical space with Scaffold Hunter
Stefan Wetzel et al.
NATURE CHEMICAL BIOLOGY (2009)
The rise of fragment-based drug discovery
Christopher W. Murray et al.
NATURE CHEMISTRY (2009)
Modification-specific proteomics: Strategies for characterization of post-translational modifications using enrichment techniques
Yingming Zhao et al.
PROTEOMICS (2009)
Site-specific incorporation of methyl- and acetyl-lysine analogues into recombinant proteins
Jiantao Guo et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2008)
Visualization of the Chemical Space in Drug Discovery
Jose L. Medina-Franco et al.
CURRENT COMPUTER-AIDED DRUG DESIGN (2008)
A critical role for Lyn in acute myeloid leukemia
Ceric Dos Santos et al.
BLOOD (2008)
AAindex: amino acid index database, progress report 2008
Shuichi Kawashima et al.
NUCLEIC ACIDS RESEARCH (2008)
Post-translational modification of heat-shock protein 90: impact on chaperone function
Bradley T. Scroggins et al.
EXPERT OPINION ON DRUG DISCOVERY (2007)
Flexible 3D pharmacophores as descriptors of dynamic biological space
James H. Nettles et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2007)
Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly
Srihari C. Sampath et al.
MOLECULAR CELL (2007)
Expanding the diversity of chemical protein modification allows post-translational mimicry
Sander I. van Kasteren et al.
NATURE (2007)
Free and chromatin-associated mono-, di-, and trimethylation of histone H4-lysine 20 during development and cell cycle progression
Dmitry Karachentsev et al.
DEVELOPMENTAL BIOLOGY (2007)
Protein kinase A-dependent translocation of Hsp90α impairs endothelial nitric-oxide synthase activity in high glucose and diabetes
Hetian Lei et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The site-specific installation of methyl-lysine analogs into recombinant histones
Matthew D. Simon et al.
CELL (2007)
Histone deacetylase inhibitors synergize p300 autoacetylation that regulates its transactivation activity and complex formation
Daniel P. Stiehl et al.
CANCER RESEARCH (2007)
An acetylation site in the middle domain of Hsp90 regulates chaperone function
Bradley T. Scroggins et al.
MOLECULAR CELL (2007)
Site-selective glycosylation of proteins: creating synthetic glycoproteins
Sander I. Van Kasteren et al.
NATURE PROTOCOLS (2007)
Discovery of selective irreversible inhibitors for Bruton's tyrosine kinase
Zhengying Pan et al.
CHEMMEDCHEM (2007)
Kinetic and mass spectrometric analysis of p300 histone acetyltransferase domain autoacetylation
Balasubramanyam Karanam et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Opinion - How many drug targets are there?
John P. Overington et al.
NATURE REVIEWS DRUG DISCOVERY (2006)
Bridging chemical and biological space: Target fishing using 2D and 3D molecular descriptors
James H. Nettles et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Reading protein modifications with interaction domains
Bruce T. Seet et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)
Global mapping of pharmacological space
Gaia V. Paolini et al.
NATURE BIOTECHNOLOGY (2006)
Molecular targets for apigenin-induced cell cycle arrest and apoptosis in prostate cancer cell xenograft
S Shukla et al.
MOLECULAR CANCER THERAPEUTICS (2006)
A general user interface for prediction servers of proteins' post-translational modification sites
Fengfeng Zhou et al.
NATURE PROTOCOLS (2006)
Rb plays a role in survival of Abl-dependent human tumor cells as a downstream effector of Abl tyrosine kinase
K Nagano et al.
ONCOGENE (2006)
Age dependent phosphorylation and deregulation of p53 in human vestibular Schwannomas
AHPP Dayalan et al.
MOLECULAR CARCINOGENESIS (2006)
Charting biologically relevant chemical space: A structural classification of natural products (SCONP)
MA Koch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Protein-protein interactions in human disease
DP Ryan et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2005)
KinasePhos: a web tool for identifying protein kinase-specific phosphorylation sites
HD Huang et al.
NUCLEIC ACIDS RESEARCH (2005)
S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities
A Martínez-Ruiz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
The principle of complementarity:: chemical versus biological space
SJ Haggarty
CURRENT OPINION IN CHEMICAL BIOLOGY (2005)
Post-translational modifications of tau protein in Alzheimer's disease
CX Gong et al.
JOURNAL OF NEURAL TRANSMISSION (2005)
Multisite protein modi. cation and intramolecular signaling
XJ Yang
ONCOGENE (2005)
Protein posttranslational modifications: The chemistry of proteome diversifications
CT Walsh et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2005)
Cytoplasmic mislocalization of p27Kip1 protein is associated with constitutive phosphorylation of Akt or protein kinase B and poor prognosis in acute myelogenous leukemia
YH Min et al.
CANCER RESEARCH (2004)
Navigating chemical space for biology and medicine
C Lipinski et al.
NATURE (2004)
Prediction of phosphorylation sites using SVMs
JH Kim et al.
BIOINFORMATICS (2004)
A 'molecular switchboard' - covalent modifications to proteins and their impact on transcription
N Khidekel et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2004)
Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage
O David et al.
CLINICAL CANCER RESEARCH (2004)
Announcing the worldwide Protein Data Bank
H Berman et al.
NATURE STRUCTURAL BIOLOGY (2003)
Improved protein-ligand docking using GOLD
ML Verdonk et al.
PROTEINS-STRUCTURE FUNCTION AND GENETICS (2003)
The process of structure-based drug design
AC Anderson
CHEMISTRY & BIOLOGY (2003)
A myristoyl/phosphotyrosine switch regulates c-Abl
O Hantschel et al.
CELL (2003)
Alternative pre-mRNA splicing and proteome expansion in metazoans
T Maniatis et al.
NATURE (2002)
Protein kinases - the major drug targets of the twenty-first century?
P Cohen
NATURE REVIEWS DRUG DISCOVERY (2002)
Phosphorylation of amyloid-β at the serine 26 residue by human cdc2 kinase
NGN Milton
NEUROREPORT (2001)
Intrinsically disordered protein
AK Dunker et al.
JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2001)
Structural mechanism for STI-571 inhibition of Abelson tyrosine kinase
T Schindler et al.
SCIENCE (2000)
分享论文
