期刊
MEDICINAL RESEARCH REVIEWS
卷 41, 期 3, 页码 1812-1834出版社
WILEY
DOI: 10.1002/med.21778
关键词
benign prostatic hyperplasia; oral microbiome; periodontal disease; prostate cancer; prostatitis
资金
- Nature Science Foundation of Hubei Province [2019FFB03902]
- Health Commission of Hubei Province Scientific Research Project [WJ2019H035]
- Fundamental Research Funds for the Central Universities [2042020kf1081]
Human microbiome research has shown the critical role of oral microbiome in health and disease, with dysbiosis being a contributory cause for diseases in multiple body systems, including a possible link between periodontal disease and prostatic disease. Research is progressing towards oral microbiome-based diagnosis and therapy for potential drug targets in systemic diseases.
Nowadays, human microbiome research is rapidly growing and emerging evidence has witnessed the critical role that oral microbiome plays in the process of human health and disease. Oral microbial dysbiosis has been confirmed as a contributory cause for diseases in multiple body systems, ranging from the oral cavity to the gastrointestinal, endocrine, immune, cardiovascular, and even nervous system. As research progressing, oral microbiome-based diagnosis and therapy are proposed and applied, which may represent potential drug targets in systemic diseases. Recent studies have uncovered the possible association between periodontal disease and prostatic disease, suggesting new prevention and therapeutic treatment for the disease by targeting periodontal pathogens. Thus, we performed this review to first explore the association between the oral microbiome and prostatic disease, according to current knowledge based on published articles, and then mainly focus on the underlying molecular and cellular mechanisms and the potential prevention and treatment derived from these mechanistic studies.
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