期刊
MEDICAL MYCOLOGY
卷 59, 期 7, 页码 734-740出版社
OXFORD UNIV PRESS
DOI: 10.1093/mmy/myaa116
关键词
Candida auris; filamentation; morphological plasticity; virulence; antifungal resistance
资金
- National Natural Science Foundation of China [82002123, 31930005, 31625002]
- National Institutes of Health (NIH) National Institute of GeneralMedical Sciences (NIGMS) [R35GM124594]
- Kamangar family
- NIH National Institute of Dental & Craniofacial Research (NIDCR) [F31DE028488]
Pathogenic Candida species, such as Candida auris, demonstrate morphological plasticity that contributes to environmental adaptation and host infection. Clinical isolates of C. auris exhibit diverse colony and cellular morphologies, including yeast, filamentous, aggregated, and elongated forms. These morphological variations are associated with different antifungal resistance and virulence properties in different cell types of C. auris.
A striking feature of pathogenic Candida species is morphological plasticity that facilitates environmental adaptation and host infection. Candida auris is an emerging multidrug-resistant fungal pathogen first described in Japan in 2009. In this study, we demonstrate that clinical isolates of C. auris have multiple colony and cellular morphologies including the yeast, filamentous, aggregated, and elongated forms. This phenotypic diversity has been observed in eight clinical isolates of C. auris representing four major genetic clades, suggesting that it could be a general characteristic. We further demonstrate that different cell types of C. auris exhibit distinct antifungal resistance and virulence properties in a Galleria mellonella infection model. Our findings imply that morphological diversity is an important biological feature of C. auris and could be a contributor to its emergence and rapid prevalence worldwide. Lay Summary Candida auris is an emerging multidrug-resistant fungal pathogen. Morphological analyses indicate that filamentation is a general feature of clinical isolates of C. auris. This ability is associated with antifungal resistance and virulence.
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