期刊
MEDICAL HYPOTHESES
卷 145, 期 -, 页码 -出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.mehy.2020.110397
关键词
Parkinson disease; beta-Adrenoreceptor; alpha-Synuclein; Ractopamine
There is still no curative treatment for the exasperating Parkinson disease, the second most common neurodegenerative disorder. Intracytoplasmic Lewy body composing of phosphorylated alpha-synuclein in dopaminergic neuronal cells has been recognized as the characteristic pathologic change and believed to be the cause of neuronal cell loss in Parkinson disease. Recently, beta-adrenoreceptor antagonist was found to be correlated with an increasing incidence of Parkinson disease and beta-adrenoreceptor agonist, capable of inhibiting gene expression of alpha-synuclein, was associated with a reduced incidence of it. Therefore, a hypothesis is raised that ractopamine, a beta-adrenoreceptor agonist used as feed additive for increasing leanness of finishing cattle and swine, might provide protective effects for Parkinson disease and lower its incidence in the population consuming meat containing ractopamine residue.
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