期刊
MEDIATORS OF INFLAMMATION
卷 2021, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2021/5318369
关键词
-
资金
- National Natural Science Foundation of China [81571946]
In this study, it was revealed that SNHG14 accelerates cellular injury in sepsis-induced AKI by activating the IRAK4/NF-kappa B and IL-6R/STAT3 signaling pathways via miR-93.
Acute kidney injury (AKI) is a common organ injury in sepsis, which leads to poor prognosis. Long noncoding RNA (lncRNA) small nucleolus RNA host gene 14 (SNHG14) was recognized to induce cell injury in LPS-induced acute lung injury and Parkinson's disease. We want to investigate the functions and mechanisms of SNHG14 in sepsis-induced AKI. Increased expression of SNHG14 was observed in LPS-induced HK-2 cells, and this was due to the activation of the TLR4/NF-kappa B pathway. In vitro studies showed that SNHG14 was involved in the oxidative stress, inflammation, and apoptosis of LPS-induced HK-2 cells. Further investigations confirmed that SNHG14 exerted the functions via miR-93 which could regulate the activation of NF-kappa B and STAT3 signaling by targeting IRAK4 and IL-6R. We also found that silencing SNHG14 also alleviated cellular injury processes of IL-1 beta and IL-6 in HK-2 cells via miR-93. We demonstrate that SNHG14 accelerates cellular injury in sepsis-induced AKI by activating IRAK4/NF-kappa B and IL-6R/STAT3 signaling via miR-93.
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