期刊
MATURITAS
卷 143, 期 -, 页码 127-131出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.maturitas.2020.10.009
关键词
Epidemiology; Diet; Manganese; Diabetes; Follow-up study
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) (Monbusho)
- MEXT (MonbuKagaku-sho) [61010076, 62010074, 63010074, 1010068, 2151065, 3151064, 4151063, 5151069, 6279102, 11181101, 17015022, 18014011, 20014026, 20390156, 26293138, 16H06277]
- Ministry of Health, Labour and Welfare, Health and Labor Sciences research grants, Japan (Research on Health Services) [H17-Kenkou-007, H18-Junkankitou[Seishuu]-Ippan-012, H19Junkankitou [Seishuu]-Ippan-012, H20-Junkankitou [Seishuu]-Ippan-013, H23-Junkankitou [Seishuu]-Ippan-005]
- Intramural Research Fund for Cardiovascular Diseases of National Cerebral and Cardiovascular Center [22-4-5]
- Comprehensive Research on Cardiovascular and Life-Style Related Diseases [H26-Junkankitou [Seisaku]-Ippan-001, H29-Junkankitou [Seishuu]-Ippan-003]
The study conducted in Japan Collaborative Cohort Study found a strong inverse association between dietary manganese intake and the risk of type 2 diabetes in women, especially in those with low iron intake. No such association was observed in men.
Background: Despite the hypoglycemic and antioxidant effects of manganese, only one recent Chinese study has investigated the association between dietary manganese intake and type 2 diabetes. Methods: We recruited 19,862 Japanese men and women in the Japan Collaborative Cohort Study. The participants completed a food frequency questionnaire at the baseline survey (1988 = 1990) and a diabetes history at both baseline and 5-year surveys. We calculated the odds ratios (95 % CIs) of the 5-year cumulative incidence of self-reported physician-diagnosed type 2 diabetes according to quartiles of dietary manganese intake. Results: Within the 5-year period, we confirmed 530 new cases of type 2 diabetes (263 in men and 267 in women) with a 5-year cumulative incidence of 2.7 % (3.6 % in men and 2.1 % in women). Higher manganese intake was inversely associated with the women's but not the men's cumulative risk of type 2 diabetes over the 5-year period. In a full model adjusted for the participants' characteristics, diabetes risk factors and a wide range of dietary variables, the multivariable odds ratios (95 %CIs) of type 2 diabetes across the increasing quartiles of manganese intake (Q1 to Q4) were 1.00, 0.97 (0.65, 1.43), 1.04 (0.67, 1.61) and 1.10 (0.64, 1.92), p-trend = 0.66 among men and 1.00, 0.74 (0.51, 1.06), 0.62 (0.41, 0.94) and 0.53 (0.31, 0.88), p-trend = 0.01 among women. The association was observed mainly for those with low iron intake in women, particularly premenopausal women. Conclusion: Strong inverse associations between dietary manganese intake and risk of type 2 diabetes were observed in women but not men.
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