期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2020.111795
关键词
Electrospinning; Cellulose; Conductive polymer; PC12 cells; Nerve tissue engineering
资金
- Natural Science Foundation of China [51473133]
- China Postdoctoral Science Foundation [2018 M633524]
- International Cooperation Project of Shaanxi Province [2015KW-016]
The study revealed that modified conductive polymer scaffolds provide more protein adsorption sites, facilitating cell attachment and growth. Compared to pure EC scaffolds, more cells were able to adhere and grow on the modified mats, exhibiting more complete and clearer morphology.
Electrospun nanofibrous scaffold is a promising implant for peripheral nerve regeneration. Herein, to investigate the effect of surface morphological features and electrical properties of scaffolds on nerve cell behavior, we modified electrospun cellulose (EC) fibrous mats with four kind of soluble conductive polymers derivates (poly (N-(methacryl ethyl) pyrrole) (PMAEPy), poly (N-(2-hydroxyethyl) pyrrole) (PHEPy), poly (3-(Ethoxycarbonyl) thiophene) (P3ECT) and poly (3-thiophenethanol) (P3TE)) by an in-situ polymerization method. The morphological characterization showed that conductive polymers formed aggregated nanoparticles and coatings on the EC nanofibers with the increased fiber diameter further affected the surface properties. Compared with pure EC scaffold, more PC12 cells were adhered and grown on modified mats, with more integral and clearer cell morphology. The results of protein adsorption study indicated that modified EC mats could provide more protein adsorption site due to their characteristic surface morphology, which is beneficial to cell adhesion and growth. The results in this study suggested that these conductive polymers modified scaffolds with special surface morphology have potential applications in neural tissue engineering.
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