期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2020.111543
关键词
Silk fibroin; Microfluidic device; Wet etching; LiBr; Adhesive paper
资金
- Natural Science Foundation of Chongqing [cstc2019jcyj-msxmX0314]
- Fundamental Research Funds for the Central Universities [XDJK2019B002]
- Chongqing Engineering Research Center for Micro-Nano Biomedical Materials and Devices
The research introduces an adhesive tape-assisted etching method to prepare RSF microfluidic devices, transforming the material from insoluble to soluble through LiBr treatment; the prepared RSF microfluidic devices exhibit good chemical resistance and strong tolerance to mechanical deformation, showing great potential for widespread application in the biomedical field.
The regenerated silk fibroin (RSF)-based microfluidic device has attracted tremendous interests in recent years due to its excellent biocompatibility, mild processing conditions, and all aqueous casting production. However, the need of a micro-fabricated mold in the manufacture process greatly hinder its practical applications. Herein, we introduce an adhesive tape-assisted etching method with LiBr solution as the etchant to prepare RSF microfluidic devices. An engraved adhesive tape is used as the mask to cover on the surface of a RSF film. Then, LiBr solution is dropped on the mask to etch RSF in concentration- and duration-dependent manners. During this process, the LiBr-treated RSF transits from insoluble beta-sheet crystallites to soluble conformations. The as-prepared RSF microfluidic devices possess good chemical resistance and excellent tolerance to mechanical deformation. RSF microfluidic systems with different patterns were fabricated to demonstrate the universality of the approach. A concentration gradient generator and a blood vessel-like channel were manufactured for the preparation of solutions with gradient pHs and the growth of living cells, respectively. The proposed strategy has great potentials in the facile fabrication of low-cost RSF microfluidic devices for tissue engineering and biomedical analysis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据