期刊
MARINE DRUGS
卷 19, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/md19010009
关键词
Penicillium oxalicum; deep sea; cold seep; phenylhydrazone; quinazoline
资金
- National Key R&D Program of China [2018YFC0310800]
- Taishan Scholar Project [tsqn201909164, ts201511060]
- Shuangbai Plan of Yantai [2018-3]
- Youth Innovation Promotion Association of CAS [Y201734]
- Research Vessel KEXUE of the National Major Science and Technology Infrastructure from the Chinese Academy of Sciences [KEXUE2018G28]
Five new compounds, including a natural phenylhydrazone-bearing steroid, were isolated from the fungus Penicillium oxalicum obtained from the deep sea cold seep, showing unique structures and inhibition properties against marine phytoplankton species and marine-derived bacteria.
Three new phenylhydrazones, penoxahydrazones A-C (compounds 1-3), and two new quinazolines, penoxazolones A (compound 4) and B (compound 5), with unique linkages were isolated from the fungus Penicillium oxalicum obtained from the deep sea cold seep. Their structures and relative configurations were assigned by analysis of 1D/2D NMR and mass spectroscopic data, and the absolute configurations of 1, 4, and 5 were established on the basis of X-ray crystallography or ECD calculations. Compound 1 represents the first natural phenylhydrazone-bearing steroid, while compounds 2 and 3 are rarely occurring phenylhydrazone tautomers. Compounds 4 and 5 are enantiomers that feature quinazoline and cinnamic acid units. Some isolates exhibited inhibition of several marine phytoplankton species and marine-derived bacteria.
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