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Recent developments in antibody derivatives against colorectal cancer; A review

期刊

LIFE SCIENCES
卷 265, 期 -, 页码 -

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2020.118791

关键词

Antibody derivatives; Colorectal cancer; Targeted therapy; Colorectal cancer markers

资金

  1. Shahid Beheshti University of Medical Sciences [17047]

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Colorectal cancer is a common and deadly disease, with conventional treatments like surgery, radiotherapy, and chemotherapy associated with side effects on normal cells. Targeted therapy using antibody fragments shows promise in inhibiting tumor growth while reducing toxicity, making it a potential alternative treatment for CRC.
Colorectal cancer (CRC) is the fourth most common cause of cancer and mortality worldwide and is the third most common cancer in men and women. Surgery, radiotherapy, and chemotherapy are conventionally used for the treatment of colorectal cancer. However, these methods are associated with various side effects on normal cells. Thus, new studies are moving towards more effective and non-invasive methods for treatment of colorectal cancer. Targeted therapy of CRC is a promising new approach to enhance the efficiency and decrease the toxicity of the treatment. In targeted therapy of CRC, antibody fragments can directly inhibit tumor cell growth and proliferation. They also can act as an ideal carrier for targeted delivery of anticancer drugs. In the present study, the structure and function of different formats of antibody fragments, immune-targeted therapy of CRC using antibody fragments will be discussed.

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