期刊
LIFE SCIENCES
卷 264, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2020.118707
关键词
Circular RNA; Metabolic-associated fatty liver disease; Hepatitis; Liver cirrhosis; Hepatocellular carcinoma
资金
- Natural Science Foundation of Zhejiang Province [LQ19H160007]
- Natural Science Foundation of Ningbo [202003N4020]
- Applied Research Projects on Nonprofit Technology of Zhejiang Province [LGF19H160012]
- Medical Scientific Research Foundation of Zhejiang Province [2018RC062]
- Social Development Major Projects of Ningbo [2016C51005]
- Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province [2019E10020]
- K. C. Wong Magna Fund in Ningbo University
Circular RNAs play a significant role in liver diseases, serving as potential diagnostic and prognostic markers with therapeutic translational value.
Circular RNAs (circRNAs) are formed from the genome through diverse back splicing and feature the closed loop. circRNAs are widely available in a variety of cells and characterized by conservation, structural stability, high abundance and tissue-specific or developmental-specific expression. Recent studies have shown that circRNAs are closely related to liver diseases, such as metabolic-associated fatty liver disease, hepatitis, liver cirrhosis and hepatocellular carcinoma. circRNAs play an important role in the progression of liver diseases, are potential diagnostic and prognostic markers, and have translational value in therapy. This article reviews the research on circRNAs in liver diseases, with a view to providing a theoretical basis and new ideas for future research and treatment of liver diseases.
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