期刊
JOURNAL OF TRANSLATIONAL MEDICINE
卷 19, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12967-020-02687-0
关键词
Time-restricted feeding; Intermittent fasting; Weight loss; Metabolic syndrome; Anthropometry; Obesity; Cardiovascular risk
资金
- Federal University of Fronteira Sul [480/GR/UFFS/2018, 1010/GR/UFFS/2018]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-CAPES
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq
TRF is an effective dietary approach for weight loss and reduction of cardiovascular risk in obese middle-aged women. It helps in reducing body weight and waist circumference, with no changes in biomarkers associated with Metabolic Syndrome.
Background: The increasing prevalence of overweight and obesity among the worldwide population has been associated with a range of adverse health consequences such as Type 2 diabetes and cardiovascular diseases. The metabolic syndrome (MetS) is a cluster of cardiometabolic abnormalities that occur more commonly in overweight individuals. Time-restricted feeding (TRF) is a dietary approach used for weight loss and overall health. TRF may be an option for those subjects who struggle with extreme restriction diets with foods that generally do not belong to an individual's habits. Objective: The purpose of this study was to determine the effect of TRF on body composition and the association of weight loss with metabolic and cardiovascular risks in obese middle-aged women. Methods: A non-randomized controlled clinical trial was performed over 3 months in obese women (TRF group, n = 20, BMI 32.53 +/- 1.13 vs. Control n = 12, BMI 34.55 +/- 1.20). The TRF protocol adopted was 16 h without any energy intake followed by 8 h of normal food intake. Main outcomes and measures: Anthropometric measurements, body composition, blood biomarkers, cardiovascular risk in 30 years (CVDRisk30y), and quality of life were evaluated at baseline and after the 3 months. Results: TRF was effective in reducing weight (similar to 4 kg), BMI, % of body fat (%BF), waist circumference from baseline without changes in blood biomarkers associated with MetS. TRF promoted a reduction in CVDRisk30y (12%) wich was moderately correlated with %BF (r = 0.62, n = 64, p < 0.001) and %MM (r = - 0.74, n = 64, p < 0.001). Conclusions:TRF protocol reduces body weight without changes in biomarkers related to MetS. In addition, the anthropometric evaluation that predicts %BF and %MM could be used as an approach to follow individuals engaged in the TRF regimen since they correlate with cardiovascular risk.
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